Reactome | SRD5A2 binds SRD5A2 inhibitors

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SRD5A2 binds SRD5A2 inhibitors Show undefined attributes

authored	[InstanceEdit:9724665] Jassal, Bijay, 2021-03-25
category	binding
compartment	[Compartment:70101] cytosol [Compartment:12045] endoplasmic reticulum membrane
created	[InstanceEdit:9705803] Jassal, Bijay, 2020-10-30
dbId	9705794
displayName	SRD5A2 binds SRD5A2 inhibitors
edited	[InstanceEdit:9757169] Jassal, Bijay, 2021-10-27 [InstanceEdit:9773839] Matthews, Lisa, 2022-05-10
eventOf	[Pathway:R-HSA-193048] Androgen biosynthesis - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-469664] SRD5A2 [endoplasmic reticulum membrane] [DefinedSet:R-ALL-9705798] SRD5A2 inhibitors [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9705809] Azasteroids: structure-activity relationships for inhibition of 5 alpha-reductase and of androgen receptor binding [LiteratureReference:9705811] A model for the turnover of dihydrotestosterone in the presence of the irreversible 5 alpha-reductase inhibitors GI198745 and finasteride [LiteratureReference:9705787] Therapeutic options in the treatment of benign prostatic hyperplasia [LiteratureReference:9705764] Human type 3 5?-reductase is expressed in peripheral tissues at higher levels than types 1 and 2 and its activity is potently inhibited by finasteride and dutasteride [LiteratureReference:9705795] Dutasteride: a review of its use in the management of prostate disorders [LiteratureReference:9705810] Finasteride for benign prostatic hyperplasia [LiteratureReference:9705792] An overview on 5alpha-reductase inhibitors [LiteratureReference:9705769] Inhibition of 5 alpha-reductase activity in human skin by zinc and azelaic acid [LiteratureReference:9705800] Azelaic acid. A review of its pharmacological properties and therapeutic efficacy in acne and hyperpigmentary skin disorders [LiteratureReference:9705763] [Mechanism of azelaic acid action in acne]
maxDepth	1
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	SRD5A2 binds SRD5A2 inhibitors
orthologousEvent	[Reaction:R-CEL-9705794] SRD5A2 binds SRD5A2 inhibitors - Caenorhabditis elegans [Reaction:R-GGA-9705794] SRD5A2 binds SRD5A2 inhibitors - Gallus gallus [Reaction:R-XTR-9705794] SRD5A2 binds SRD5A2 inhibitors - Xenopus tropicalis [Reaction:R-DRE-9705794] SRD5A2 binds SRD5A2 inhibitors - Danio rerio [Reaction:R-BTA-9705794] SRD5A2 binds SRD5A2 inhibitors - Bos taurus [Reaction:R-CFA-9705794] SRD5A2 binds SRD5A2 inhibitors - Canis familiaris [Reaction:R-RNO-9705794] SRD5A2 binds SRD5A2 inhibitors - Rattus norvegicus [Reaction:R-MMU-9705794] SRD5A2 binds SRD5A2 inhibitors - Mus musculus
output	[Complex:R-HSA-9705766] SRD5A2:SRD5A2 inhibitors [endoplasmic reticulum membrane]
releaseDate	2022-06-09
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9767610] Huddart, Rachel, 2022-03-01
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9705794
summation	[Summation:9705813] The conversion of testosterone (TEST) to the most potent and...

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[Pathway:R-HSA-193048] Androgen biosynthesis

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