Reactome | HMGCR dimer binds statins

Schema > Reaction > Entries

HMGCR dimer binds statins Show undefined attributes

authored	[InstanceEdit:9705585] Jassal, Bijay, 2020-10-27
category	binding
compartment	[Compartment:70101] cytosol [Compartment:12045] endoplasmic reticulum membrane
created	[InstanceEdit:9705585] Jassal, Bijay, 2020-10-27
dbId	9705584
displayName	HMGCR dimer binds statins
edited	[InstanceEdit:9705585] Jassal, Bijay, 2020-10-27 [InstanceEdit:9773839] Matthews, Lisa, 2022-05-10
eventOf	[Pathway:R-HSA-9969896] Lanosterol biosynthesis - Homo sapiens
input	[Complex:R-HSA-191277] HMGCR dimer [endoplasmic reticulum membrane] [DefinedSet:R-ALL-9705575] statins [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9705598] Binding thermodynamics of statins to HMG-CoA reductase [LiteratureReference:9705573] An Atomic-Level Perspective of HMG-CoA-Reductase: The Target Enzyme to Treat Hypercholesterolemia [LiteratureReference:9705579] Structural mechanism for statin inhibition of 3-hydroxy-3-methylglutaryl coenzyme A reductase [LiteratureReference:9705572] Structural mechanism for statin inhibition of HMG-CoA reductase
maxDepth	1
modified	[InstanceEdit:11080360] Weiser, Joel, 2026-03-16
name	HMGCR dimer binds statins
orthologousEvent	[Reaction:R-BTA-9705584] HMGCR dimer binds statins - Bos taurus [Reaction:R-SCE-9705584] HMGCR dimer binds statins - Saccharomyces cerevisiae [Reaction:R-SPO-9705584] HMGCR dimer binds statins - Schizosaccharomyces pombe [Reaction:R-DDI-9705584] HMGCR dimer binds statins - Dictyostelium discoideum [Reaction:R-CEL-9705584] HMGCR dimer binds statins - Caenorhabditis elegans [Reaction:R-DME-9705584] HMGCR dimer binds statins - Drosophila melanogaster [Reaction:R-GGA-9705584] HMGCR dimer binds statins - Gallus gallus [Reaction:R-XTR-9705584] HMGCR dimer binds statins - Xenopus tropicalis [Reaction:R-DRE-9705584] HMGCR dimer binds statins - Danio rerio [Reaction:R-SSC-9705584] HMGCR dimer binds statins - Sus scrofa [Reaction:R-CFA-9705584] HMGCR dimer binds statins - Canis familiaris [Reaction:R-RNO-9705584] HMGCR dimer binds statins - Rattus norvegicus [Reaction:R-MMU-9705584] HMGCR dimer binds statins - Mus musculus
output	[Complex:R-HSA-9705595] HMGCR dimer:statins [endoplasmic reticulum membrane]
precedingEvent	[Reaction:R-HSA-9757010] SLCO1B1,1B3,2B1-3 transport ATV from extracelluar region to cytosol - Homo sapiens
releaseDate	2022-06-09
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9767610] Huddart, Rachel, 2022-03-01
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9705584
summation	[Summation:9705590] Dimeric 3-hydroxy-3-methyl glutaryl coenzyme A reductase (HM...
updateTrackers	[UpdateTracker:9971943] Update Tracker - [Reaction:9705584] HMGCR dimer binds statins - v95:[removeLiteratureReference]

Referrals

(updatedInstance)	[UpdateTracker:9971943] Update Tracker - [Reaction:9705584] HMGCR dimer binds statins - v95:[removeLiteratureReference]
(hasEvent)	[Pathway:R-HSA-9969896] Lanosterol biosynthesis

Cite Us!