Reactome | HMGCR dimer binds statins

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HMGCR dimer binds statins Show undefined attributes

category	binding
compartment	[Compartment:70101] cytosol [Compartment:12045] endoplasmic reticulum membrane
created	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
dbId	10988681
displayName	HMGCR dimer binds statins
eventOf	[Pathway:R-CEL-9969896] Lanosterol biosynthesis - Caenorhabditis elegans
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-9705584] HMGCR dimer binds statins - Homo sapiens
input	[Complex:R-CEL-191277] HMGCR dimer [endoplasmic reticulum membrane] [DefinedSet:R-ALL-9705575] statins [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	HMGCR dimer binds statins
output	[Complex:R-CEL-9705595] HMGCR dimer:statins [endoplasmic reticulum membrane]
precedingEvent	[Reaction:R-CEL-9757010] SLCO1B1,1B3,2B1-3 transport ATV from extracelluar region to cytosol - Caenorhabditis elegans
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:68320] Caenorhabditis elegans
stId	R-CEL-9705584
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-CEL-9969896] Lanosterol biosynthesis
(inferredTo)	[Reaction:R-HSA-9705584] HMGCR dimer binds statins