Reactome | FLT3 fusion dimers autophosphorylate

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FLT3 fusion dimers autophosphorylate Show undefined attributes

authored	[InstanceEdit:9706566] Rothfels, Karen, 2020-11-06
catalystActivity	[CatalystActivity:9703427] protein tyrosine kinase activity of FLT3 fusion dimers [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9703431] Rothfels, Karen, 2020-10-06
crossReference	[DatabaseIdentifier:12020745] Mondo:0004992
dbId	9703437
disease	[Disease:1500689] cancer
displayName	FLT3 fusion dimers autophosphorylate
edited	[InstanceEdit:9706566] Rothfels, Karen, 2020-11-06
eventOf	[Pathway:R-HSA-9703465] Signaling by FLT3 fusion proteins - Homo sapiens
followingEvent	[BlackBoxEvent:R-HSA-9703435] FLT3 fusions activate STAT5 - Homo sapiens [Reaction:R-HSA-9703442] Phosphorylated FLT3 fusions bind GRB2 - Homo sapiens
input	8 × [SimpleEntity:R-ALL-113592] ATP [cytosol] [CandidateSet:R-HSA-9703409] FLT3 fusion dimers [cytosol]
isChimeric	false
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:9703225] FLT3 is fused to ETV6 in a myeloproliferative disorder with hypereosinophilia and a t(12;13)(p13;q12) translocation [LiteratureReference:9703191] A constitutively active SPTBN1-FLT3 fusion in atypical chronic myeloid leukemia is sensitive to tyrosine kinase inhibitors and immunotherapy [LiteratureReference:9703263] A novel t(3;13)(q13;q12) translocation fusing FLT3 with GOLGB1: toward myeloid/lymphoid neoplasms with eosinophilia and rearrangement of FLT3? [LiteratureReference:9604770] Direct binding of Grb2 has an important role in the development of myeloproliferative disease induced by ETV6/FLT3 [LiteratureReference:9703182] The juxtamembrane domain in ETV6/FLT3 is critical for PIM-1 up-regulation and cell proliferation
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	FLT3 fusion dimers autophosphorylate
output	8 × [SimpleEntity:R-ALL-29370] ADP [cytosol] [CandidateSet:R-HSA-9703372] p-Y FLT3 fusion dimers [cytosol]
precedingEvent	[Reaction:R-HSA-9703433] Ligand-independent dimerization of FLT3 fusion proteins - Homo sapiens
releaseDate	2020-12-08
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9706568] Kazi, Julhash U, 2020-11-06
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9703437
summation	[Summation:9703417] After ligand-independent dimerization, FLT3 fusion proteins ...

Referrals

(precedingEvent)	[BlackBoxEvent:R-HSA-9703435] FLT3 fusions activate STAT5 [Reaction:R-HSA-9703442] Phosphorylated FLT3 fusions bind GRB2
(hasEvent)	[Pathway:R-HSA-9703465] Signaling by FLT3 fusion proteins