After ligand-independent dimerization, FLT3 fusion proteins are trans-autophosophorylated on tyrosine residues, activating downstream signaling through PI3K/AKT, MAP kinase and STAT5 pathways (Vu et al, 2006; Grand et al, 2007; Vu et al, 2009; Troadec et al, 2017; Chonabayashi et al, 2013; reviewed in Kazi and Roonstrand, 2019).
Sato, Y, Vu, HA, Motoji, T, Sakaki, Y, Xinh, PT, Tokunaga, K, Toyoda, A, Masuda, M
Petit, B, Dobbelstein, S, Chauzeix, J, Touati, M, Gachard, N, Faumont, N, Bertrand, P, Troadec, E, Trimoreau, F, Bordessoule, D, Bastard, C, Feuillard, J
Xinh, PT, Vu, HA, Kano, Y, Tokunaga, K, Sato, Y
Grand, FH, Zhang, L, Russell, NH, Cross, NC, Chase, A, Iqbal, S
Ishikawa, T, Kawamata, S, Ohno, T, Chonabayashi, K, Hishizawa, M, Uchiyama, T, Nagai, Y, Takaori-Kondo, A
protein tyrosine kinase activity of FLT3 fusion dimers [cytosol]
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