Reactome | FLT3 N676D [plasma membrane]

Schema > EntityWithAccessionedSequence > Entries

compartment	[Compartment:876] plasma membrane
componentOf	[Complex:R-HSA-9702897] FLT3 N676D dimer [plasma membrane] - Homo sapiens
created	[InstanceEdit:9702894] Rothfels, Karen, 2020-10-02
dbId	9702895
disease	[Disease:1500689] cancer [Disease:9630839] acute myeloid leukemia
displayName	FLT3 N676D [plasma membrane]
endCoordinate	993
hasModifiedResidue	[ReplacedResidue:9702893] L-asparagine 676 replaced with L-aspartic acid
inDisease	true
literatureReference	[LiteratureReference:9699384] The secondary FLT3-ITD F691L mutation induces resistance to AC220 in FLT3-ITD+ AML but retains in vitro sensitivity to PKC412 and Sunitinib
memberOf	[DefinedSet:R-HSA-9699525] quizartinib-resistant FLT3 mutants [plasma membrane] - Homo sapiens [DefinedSet:R-HSA-9699522] sorafenib-sensitive FLT3 mutants [plasma membrane] - Homo sapiens [DefinedSet:R-HSA-9699532] sunitinib-sensitive FLT3 mutants [plasma membrane] - Homo sapiens
name	FLT3 N676D
referenceEntity	[ReferenceGeneProduct:54914] UniProt:P36888 FLT3
referenceType	ReferenceGeneProduct
schemaClass	EntityWithAccessionedSequence
species	[Species:48887] Homo sapiens
stId	R-HSA-9702895
startCoordinate	27

(hasComponent)	[Complex:R-HSA-9702897] FLT3 N676D dimer [plasma membrane]
(hasMember)	[DefinedSet:R-HSA-9699525] quizartinib-resistant FLT3 mutants [plasma membrane] [DefinedSet:R-HSA-9699532] sunitinib-sensitive FLT3 mutants [plasma membrane] [DefinedSet:R-HSA-9699522] sorafenib-sensitive FLT3 mutants [plasma membrane]