Reactome | ALK L1198F [plasma membrane]

Schema > EntityWithAccessionedSequence > Entries

compartment	[Compartment:876] plasma membrane
componentOf	[Complex:R-HSA-9701829] ALK L1198F dimer [plasma membrane] - Homo sapiens [Complex:R-HSA-9701829] ALK L1198F dimer [plasma membrane] - Homo sapiens
created	[InstanceEdit:9701436] Rothfels, Karen, 2020-09-26
crossReference	[DatabaseIdentifier:12021093] Mondo:0015075 [DatabaseIdentifier:9701285] COSMIC:COSM9311666 [DatabaseIdentifier:9701289] COSMIC:COSV66556391
dbId	9701434
disease	[Disease:1981182] lung squamous cell carcinoma [Disease:6802256] thyroid carcinoma
displayName	ALK L1198F [plasma membrane]
endCoordinate	1620
hasModifiedResidue	[ReplacedResidue:9701415] L-leucine 1198 replaced with L-phenylalanine
inDisease	true
literatureReference	[LiteratureReference:9700350] The ALK inhibitor ceritinib overcomes crizotinib resistance in non-small cell lung cancer [LiteratureReference:9701769] Anaplastic thyroid cancers harbor novel oncogenic mutations of the ALK gene
maxDepth	1
memberOf	[CandidateSet:R-HSA-9700083] kinase domain ALK mutants [plasma membrane] - Homo sapiens
modified	[InstanceEdit:9701908] Rothfels, Karen, 2020-09-28
name	ALK L1198F ALK tyrosine kinase receptor ALK_HUMAN
referenceEntity	[ReferenceGeneProduct:uniprot:Q9UM73] UniProt:Q9UM73 ALK
referenceType	ReferenceGeneProduct
schemaClass	EntityWithAccessionedSequence
species	[Species:48887] Homo sapiens
stId	R-HSA-9701434
startCoordinate	19

(hasMember)	[CandidateSet:R-HSA-9700083] kinase domain ALK mutants [plasma membrane]
(hasComponent)	[Complex:R-HSA-9701829] ALK L1198F dimer [plasma membrane]

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