Reactome | ALK S1206Y [plasma membrane]

Schema > EntityWithAccessionedSequence > Entries

compartment	[Compartment:876] plasma membrane
componentOf	[Complex:R-HSA-9701482] ALK S1206Y dimer [plasma membrane] - Homo sapiens [Complex:R-HSA-9701482] ALK S1206Y dimer [plasma membrane] - Homo sapiens
created	[InstanceEdit:9701436] Rothfels, Karen, 2020-09-26
crossReference	[DatabaseIdentifier:12020833] Mondo:0005061 [DatabaseIdentifier:9701280] COSMIC:COSV66566818
dbId	9701426
disease	[Disease:8853117] lung adenocarcinoma
displayName	ALK S1206Y [plasma membrane]
endCoordinate	1620
hasModifiedResidue	[ReplacedResidue:9701430] L-serine 1206 replaced with L-tyrosine
inDisease	true
literatureReference	[LiteratureReference:9700350] The ALK inhibitor ceritinib overcomes crizotinib resistance in non-small cell lung cancer
maxDepth	1
name	ALK S1206Y ALK tyrosine kinase receptor ALK_HUMAN
referenceEntity	[ReferenceGeneProduct:uniprot:Q9UM73] UniProt:Q9UM73 ALK
referenceType	ReferenceGeneProduct
schemaClass	EntityWithAccessionedSequence
species	[Species:48887] Homo sapiens
stId	R-HSA-9701426
startCoordinate	19

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