Reactome | NVP-TAE684-resistant ALK mutants [plasma membrane]

Schema > DefinedSet > Entries

NVP-TAE684-resistant ALK mutants [plasma membrane] Show undefined attributes

compartment	[Compartment:876] plasma membrane
consumedByEvent	[FailedReaction:R-HSA-9700114] NVP-TAE684-resistant ALK mutants don't bind NVP-TAE684 - Homo sapiens
created	[InstanceEdit:9700562] Rothfels, Karen, 2020-09-16
crossReference	[DatabaseIdentifier:12020745] Mondo:0004992
dbId	9700568
disease	[Disease:1500689] cancer
displayName	NVP-TAE684-resistant ALK mutants [plasma membrane]
hasMember	[Complex:R-HSA-9701839] ALK L1152R dimer [plasma membrane] - Homo sapiens [Complex:R-HSA-9700533] ALK I1171N dimer [plasma membrane] - Homo sapiens [Complex:R-HSA-9701840] ALK L1198P dimer [plasma membrane] - Homo sapiens [Complex:R-HSA-9701827] ALK D1203N dimer [plasma membrane] - Homo sapiens [Complex:R-HSA-9700557] ALK A1234T dimer [plasma membrane] - Homo sapiens
inDisease	true
literatureReference	[LiteratureReference:9700412] Activating mutations in ALK provide a therapeutic target in neuroblastoma [LiteratureReference:9701779] A novel ALK secondary mutation and EGFR signaling cause resistance to ALK kinase inhibitors [LiteratureReference:9701773] ALK mutations conferring differential resistance to structurally diverse ALK inhibitors [LiteratureReference:9700339] Crizotinib-resistant NPM-ALK mutants confer differential sensitivity to unrelated Alk inhibitors [LiteratureReference:9717267] TKI sensitivity patterns of novel kinase-domain mutations suggest therapeutic opportunities for patients with resistant ALK+ tumors
maxDepth	3
modified	[InstanceEdit:9757297] Rothfels, Karen, 2021-10-28
name	NVP-TAE684-resistant ALK mutants
schemaClass	DefinedSet
species	[Species:48887] Homo sapiens
stId	R-HSA-9700568

Referrals

(input)	[FailedReaction:R-HSA-9700114] NVP-TAE684-resistant ALK mutants don't bind NVP-TAE684
(diseaseEntity)	[EntityFunctionalStatus:9717337] loss_of_function of NVP-TAE684-resistant ALK mutants [plasma membrane]

© 2026 Reactome

Cite Us!