Reactome | crizotinib-sensitive ALK mutants [cytosol]

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crizotinib-sensitive ALK mutants [cytosol] Show undefined attributes

compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:9700530] Rothfels, Karen, 2020-09-16
crossReference	[DatabaseIdentifier:12020745] Mondo:0004992
dbId	9700529
disease	[Disease:1500689] cancer
displayName	crizotinib-sensitive ALK mutants [cytosol]
hasMember	[Complex:R-HSA-9700005] ALK F1174V dimer [plasma membrane] - Homo sapiens [Complex:R-HSA-9701829] ALK L1198F dimer [plasma membrane] - Homo sapiens [Complex:R-HSA-9713496] BCL11A(1-219)InsDHPPA-ALK(1058-1620) fusion dimer [cytosol] - Homo sapiens [Complex:R-HSA-9713494] BIRC6(1-958)-ALK(1058-1620) fusion dimer [cytosol] - Homo sapiens [Complex:R-HSA-9713509] EIF2AK3(30-144)-ALK(1058-1620) fusion dimer [cytosol] - Homo sapiens [Complex:R-HSA-9699985] EML4(1-223)-ALK(1059-1620) fusion dimer [cytosol] - Homo sapiens [Complex:R-HSA-9699976] EML4(1-223)insKMSTREKNSQV -ALK(1059-1620) fusion dimer [cytosol] - Homo sapiens [Complex:R-HSA-9700022] EML4(1-486)-ALK(1058-1620) fusion dimer [cytosol] - Homo sapiens [Complex:R-HSA-9713500] FN1(32-1201)-ALK(1022-1620) fusion dimer [plasma membrane] - Homo sapiens [Complex:R-HSA-9712019] HIP1(1-1019)-ALK(1058-1620) dimer [cytosol] - Homo sapiens [Complex:R-HSA-9712025] HIP1(1-963)-ALK(1058-1620) fusion dimer [cytosol] - Homo sapiens [Complex:R-HSA-9712023] HIP1(1-719)InsL-ALK(1059-1620) fusion dimer [cytosol] - Homo sapiens [Complex:R-HSA-9713504] PPM1B(2-282)-ALK(1058-1620) fusion dimer [cytosol] - Homo sapiens [Complex:R-HSA-9713493] PRKAR1A(1-183)-ALK(1058-1620) fusion dimer [cytosol] - Homo sapiens [Complex:R-HSA-9700523] STRN(1-137)-ALK(1058-1620) fusion dimer [cytosol] - Homo sapiens [Complex:R-HSA-9699999] NPM1(1-117)-ALK(1058-1620) fusion dimer [cytosol] - Homo sapiens
inDisease	true
literatureReference	[LiteratureReference:9700343] Therapeutic strategies to overcome crizotinib resistance in non-small cell lung cancers harboring the fusion oncogene EML4-ALK [LiteratureReference:9713378] Identification of anaplastic lymphoma kinase as a potential therapeutic target in ovarian cancer [LiteratureReference:9713340] BIRC6-ALK, a Novel Fusion Gene in ALK Break-Apart FISH-Negative Lung Adenocarcinoma, Responds to Crizotinib [LiteratureReference:9713415] Comprehensive Genomic Profiling Identifies a Subset of Crizotinib-Responsive ALK-Rearranged Non-Small Cell Lung Cancer Not Detected by Fluorescence In Situ Hybridization [LiteratureReference:9713357] Identification of a novel crizotinib-sensitive BCL11A-ALK gene fusion in a nonsmall cell lung cancer patient [LiteratureReference:9700357] Treatment Efficacy and Resistance Mechanisms Using the Second-Generation ALK Inhibitor AP26113 in Human NPM-ALK-Positive Anaplastic Large Cell Lymphoma [LiteratureReference:9716593] Molecular Modeling of ALK L1198F and/or G1202R Mutations to Determine Differential Crizotinib Sensitivity [LiteratureReference:9701767] EML4-ALK mutations in lung cancer that confer resistance to ALK inhibitors [LiteratureReference:9710786] RAS-MAPK dependence underlies a rational polytherapy strategy in EML4-ALK-positive lung cancer [LiteratureReference:9711845] Identification of a novel HIP1-ALK fusion variant in Non-Small-Cell Lung Cancer (NSCLC) and discovery of ALK I1171 (I1171N/S) mutations in two ALK-rearranged NSCLC patients with resistance to Alectinib [LiteratureReference:9711777] HIP1-ALK, a novel ALK fusion variant that responds to crizotinib [LiteratureReference:9711859] HIP1-ALK, a novel fusion protein identified in lung adenocarcinoma [LiteratureReference:9711850] Identification of the transforming STRN-ALK fusion as a potential therapeutic target in the aggressive forms of thyroid cancer [LiteratureReference:9843025] IL10RA modulates crizotinib sensitivity in NPM1-ALK+ anaplastic large cell lymphoma
maxDepth	3
memberOf	[DefinedSet:R-HSA-9699981] type I TKI sensitive ALK mutants [plasma membrane] - Homo sapiens
modified	[InstanceEdit:9850948] Rothfels, Karen, 2023-10-12
name	crizotinib-sensitive ALK mutants
schemaClass	DefinedSet
species	[Species:48887] Homo sapiens
stId	R-HSA-9700529
updateTrackers	[UpdateTracker:9906356] Update Tracker - [DefinedSet:9700529] crizotinib-sensitive ALK mutants [cytosol] - v87:[addHasMember, addLiteratureReference]

Referrals

(updatedInstance)	[UpdateTracker:9906356] Update Tracker - [DefinedSet:9700529] crizotinib-sensitive ALK mutants [cytosol] - v87:[addHasMember, addLiteratureReference]
(hasMember)	[DefinedSet:R-HSA-9699981] type I TKI sensitive ALK mutants [plasma membrane]

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