Reactome | extracellular domain ALK mutants [plasma membrane]

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extracellular domain ALK mutants [plasma membrane] Show undefined attributes

compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:9700089] Rothfels, Karen, 2020-09-14
crossReference	[DatabaseIdentifier:12020745] Mondo:0004992
dbId	9700087
disease	[Disease:1500689] cancer
displayName	extracellular domain ALK mutants [plasma membrane]
hasCandidate	[EntityWithAccessionedSequence:R-HSA-9715260] ALK G881D [plasma membrane] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-9715267] ALK S413N [plasma membrane] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-9715265] ALK V597A [plasma membrane] - Homo sapiens
hasMember	[EntityWithAccessionedSequence:R-HSA-9715263] ALK H694R [plasma membrane] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-9723870] ALK H224_G318del [plasma membrane] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-9723869] ALK del318-782 [plasma membrane] - Homo sapiens
inDisease	true
literatureReference	[LiteratureReference:9723810] Aberrant activation of ALK kinase by a novel truncated form ALK protein in neuroblastoma [LiteratureReference:9723824] Characterization of rearrangements involving the ALK gene reveals a novel truncated form associated with tumor aggressiveness in neuroblastoma [LiteratureReference:9715255] Identification of oncogenic point mutations and hyperphosphorylation of anaplastic lymphoma kinase in lung cancer
maxDepth	2
memberOf	[DefinedSet:R-HSA-9700567] ALK point mutants [plasma membrane] - Homo sapiens
modified	[InstanceEdit:9723899] Rothfels, Karen, 2021-03-18
name	extracellular domain ALK mutants
schemaClass	CandidateSet
species	[Species:48887] Homo sapiens
stId	R-HSA-9700087

Referrals

(hasMember)

[DefinedSet:R-HSA-9700567] ALK point mutants [plasma membrane]

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