Reactome | NVP-TAE684-sensitive ALK mutants [cytosol]

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NVP-TAE684-sensitive ALK mutants [cytosol] Show undefined attributes

compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:9700089] Rothfels, Karen, 2020-09-14
crossReference	[DatabaseIdentifier:12020745] Mondo:0004992
dbId	9700081
disease	[Disease:1500689] cancer
displayName	NVP-TAE684-sensitive ALK mutants [cytosol]
hasMember	[Complex:R-HSA-9699987] ALK F1174L dimer [plasma membrane] - Homo sapiens [Complex:R-HSA-9715315] ALK V1180L dimer [plasma membrane] - Homo sapiens [Complex:R-HSA-9700520] ALK L1196M dimer [plasma membrane] - Homo sapiens [Complex:R-HSA-9700521] ALK L1196Q dimer [plasma membrane] - Homo sapiens [Complex:R-HSA-9701832] ALK G1269S dimer [plasma membrane] - Homo sapiens [Complex:R-HSA-9700021] ALK R1275Q dimer [plasma membrane] - Homo sapiens [Complex:R-HSA-9710894] CLTC(2-1634)-ALK(1059-1620) fusion dimer [cytosol] - Homo sapiens [Complex:R-HSA-9699976] EML4(1-223)insKMSTREKNSQV -ALK(1059-1620) fusion dimer [cytosol] - Homo sapiens [Complex:R-HSA-9713500] FN1(32-1201)-ALK(1022-1620) fusion dimer [plasma membrane] - Homo sapiens [Complex:R-HSA-9699999] NPM1(1-117)-ALK(1058-1620) fusion dimer [cytosol] - Homo sapiens [Complex:R-HSA-9700523] STRN(1-137)-ALK(1058-1620) fusion dimer [cytosol] - Homo sapiens
inDisease	true
literatureReference	[LiteratureReference:9699697] Identification of NVP-TAE684, a potent, selective, and efficacious inhibitor of NPM-ALK [LiteratureReference:9701773] ALK mutations conferring differential resistance to structurally diverse ALK inhibitors [LiteratureReference:9710767] Inhibition of anaplastic lymphoma kinase (ALK) activity provides a therapeutic approach for CLTC-ALK-positive human diffuse large B cell lymphomas [LiteratureReference:9713378] Identification of anaplastic lymphoma kinase as a potential therapeutic target in ovarian cancer [LiteratureReference:9700339] Crizotinib-resistant NPM-ALK mutants confer differential sensitivity to unrelated Alk inhibitors
maxDepth	3
memberOf	[DefinedSet:R-HSA-9699981] type I TKI sensitive ALK mutants [plasma membrane] - Homo sapiens
modified	[InstanceEdit:9716606] Rothfels, Karen, 2021-02-22
name	NVP-TAE684-sensitive ALK mutants
schemaClass	DefinedSet
species	[Species:48887] Homo sapiens
stId	R-HSA-9700081

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[DefinedSet:R-HSA-9699981] type I TKI sensitive ALK mutants [plasma membrane]

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