Reactome | NPM1(1-117)-p-7Y-ALK(1058-1620) fusion [cytosol]

Schema > EntityWithAccessionedSequence > Entries

NPM1(1-117)-p-7Y-ALK(1058-1620) fusion [cytosol] Show undefined attributes

compartment	[Compartment:70101] cytosol
componentOf	[Complex:R-HSA-9699991] NPM1(1-117)-p-7Y ALK(1058-1620) fusion dimer [cytosol] - Homo sapiens [Complex:R-HSA-9699991] NPM1(1-117)-p-7Y ALK(1058-1620) fusion dimer [cytosol] - Homo sapiens
created	[InstanceEdit:9699845] Rothfels, Karen, 2020-09-14
crossReference	[DatabaseIdentifier:12021097] Mondo:0005062
dbId	9699861
disease	[Disease:6802338] lymphoma [Disease:1500689] cancer
displayName	NPM1(1-117)-p-7Y-ALK(1058-1620) fusion [cytosol]
endCoordinate	117
hasModifiedResidue	[FragmentInsertionModification:9699804] Insertion of residues 1058 to 1620 at 118 from UniProt:Q9UM73 ALK [ModifiedResidue:9699868] O4'-phospho-L-tyrosine at 1278 [ModifiedResidue:9699844] O4'-phospho-L-tyrosine at 1282 [ModifiedResidue:9699911] O4'-phospho-L-tyrosine at 1283 [ModifiedResidue:9699796] O4'-phospho-L-tyrosine at 1096 [ModifiedResidue:9699876] O4'-phospho-L-tyrosine at 1359 [ModifiedResidue:9699886] O4'-phospho-L-tyrosine at 1507 [ModifiedResidue:9699803] O4'-phospho-L-tyrosine at 1604
inDisease	true
literatureReference	[LiteratureReference:9699651] Characterization of the transforming activity of p80, a hyperphosphorylated protein in a Ki-1 lymphoma cell line with chromosomal translocation t(2;5)
maxDepth	1
modified	[InstanceEdit:9832244] Orlic-Milacic, Marija, 2023-03-29
name	NPM1(1-117)-p-7Y-ALK(1058-1620) fusion Nucleophosmin B23 NPM_HUMAN
referenceEntity	[ReferenceGeneProduct:uniprot:P06748] UniProt:P06748 NPM1
referenceType	ReferenceGeneProduct
schemaClass	EntityWithAccessionedSequence
species	[Species:48887] Homo sapiens
stId	R-HSA-9699861
startCoordinate	1
updateTrackers	[UpdateTracker:9905774] Update Tracker - [EntityWithAccessionedSequence:9699861] NPM1(1-117)-p-7Y-ALK(1058-1620) fusion [cytosol] - v85:[modifyName]

Referrals

(updatedInstance)	[UpdateTracker:9905774] Update Tracker - [EntityWithAccessionedSequence:9699861] NPM1(1-117)-p-7Y-ALK(1058-1620) fusion [cytosol] - v85:[modifyName]
(hasComponent)	[Complex:R-HSA-9699991] NPM1(1-117)-p-7Y ALK(1058-1620) fusion dimer [cytosol]

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