Reactome | ALK I1171N [plasma membrane]

Schema > EntityWithAccessionedSequence > Entries

compartment	[Compartment:876] plasma membrane
componentOf	[Complex:R-HSA-9700533] ALK I1171N dimer [plasma membrane] - Homo sapiens [Complex:R-HSA-9700533] ALK I1171N dimer [plasma membrane] - Homo sapiens
created	[InstanceEdit:9699845] Rothfels, Karen, 2020-09-14
crossReference	[DatabaseIdentifier:12021383] Mondo:0005072 [DatabaseIdentifier:9699878] COSMIC:COSM9278044 [DatabaseIdentifier:9699920] COSMIC:COSV66556242
dbId	9699828
disease	[Disease:1247848] non-small cell lung carcinoma [Disease:9671652] neuroblastoma [Disease:8853117] lung adenocarcinoma
displayName	ALK I1171N [plasma membrane]
endCoordinate	1620
hasModifiedResidue	[ReplacedResidue:9699855] L-isoleucine 1171 replaced with L-asparagine
inDisease	true
literatureReference	[LiteratureReference:9700339] Crizotinib-resistant NPM-ALK mutants confer differential sensitivity to unrelated Alk inhibitors
maxDepth	1
memberOf	[CandidateSet:R-HSA-9700083] kinase domain ALK mutants [plasma membrane] - Homo sapiens
modified	[InstanceEdit:9700452] Rothfels, Karen, 2020-09-16
name	ALK I1171N ALK tyrosine kinase receptor ALK_HUMAN
referenceEntity	[ReferenceGeneProduct:uniprot:Q9UM73] UniProt:Q9UM73 ALK
referenceType	ReferenceGeneProduct
schemaClass	EntityWithAccessionedSequence
species	[Species:48887] Homo sapiens
stId	R-HSA-9699828
startCoordinate	19

(hasMember)	[CandidateSet:R-HSA-9700083] kinase domain ALK mutants [plasma membrane]
(hasComponent)	[Complex:R-HSA-9700533] ALK I1171N dimer [plasma membrane]

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