Reactome | crenolanib-resistant FLT3 mutants [plasma membrane]

Schema > DefinedSet > Entries

compartment	[Compartment:876] plasma membrane
consumedByEvent	[FailedReaction:R-HSA-9702583] crenolanib-resistant FLT3 mutants don't bind crenolanib - Homo sapiens
created	[InstanceEdit:9699524] Rothfels, Karen, 2020-09-14
crossReference	[DatabaseIdentifier:12020745] Mondo:0004992
dbId	9699539
disease	[Disease:1500689] cancer
displayName	crenolanib-resistant FLT3 mutants [plasma membrane]
hasMember	[Complex:R-HSA-9695762] FLT3 F691L dimer [plasma membrane] - Homo sapiens [Complex:R-HSA-9682341] FLT3 D835H dimer [plasma membrane] - Homo sapiens
inDisease	true
literatureReference	[LiteratureReference:9699248] Crenolanib is a potent inhibitor of FLT3 with activity against resistance-conferring point mutants
maxDepth	3
modified	[InstanceEdit:9703072] Rothfels, Karen, 2020-10-05
name	crenolanib-resistant FLT3 mutants
schemaClass	DefinedSet
species	[Species:48887] Homo sapiens
stId	R-HSA-9699539

(input)	[FailedReaction:R-HSA-9702583] crenolanib-resistant FLT3 mutants don't bind crenolanib
(diseaseEntity)	[EntityFunctionalStatus:9702584] loss_of_function of crenolanib-resistant FLT3 mutants [plasma membrane]

Cite Us!