Reactome | gilteritinib-resistant FLT3 mutants [plasma membrane]

Schema > DefinedSet > Entries

compartment	[Compartment:876] plasma membrane
consumedByEvent	[FailedReaction:R-HSA-9702589] gilteritinib-resistant FLT3 mutants don't bind gilteritinib - Homo sapiens
created	[InstanceEdit:9699524] Rothfels, Karen, 2020-09-14
crossReference	[DatabaseIdentifier:12020745] Mondo:0004992
dbId	9699533
disease	[Disease:1500689] cancer
displayName	gilteritinib-resistant FLT3 mutants [plasma membrane]
hasMember	[Complex:R-HSA-9695762] FLT3 F691L dimer [plasma membrane] - Homo sapiens [Complex:R-HSA-9702905] FLT3 F691I dimer [plasma membrane] - Homo sapiens
inDisease	true
literatureReference	[LiteratureReference:9699314] Gilteritinib is a clinically active FLT3 inhibitor with broad activity against FLT3 kinase domain mutations [LiteratureReference:9699354] Preclinical studies of gilteritinib, a next-generation FLT3 inhibitor
maxDepth	3
modified	[InstanceEdit:9702941] Rothfels, Karen, 2020-10-02
name	gilteritinib-resistant FLT3 mutants
schemaClass	DefinedSet
species	[Species:48887] Homo sapiens
stId	R-HSA-9699533

(input)	[FailedReaction:R-HSA-9702589] gilteritinib-resistant FLT3 mutants don't bind gilteritinib
(diseaseEntity)	[EntityFunctionalStatus:9702588] loss_of_function of gilteritinib-resistant FLT3 mutants [plasma membrane]

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