Reactome | midostaurin-sensitive FLT3 mutants [plasma membrane]

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midostaurin-sensitive FLT3 mutants [plasma membrane] Show undefined attributes

compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:9699524] Rothfels, Karen, 2020-09-14
crossReference	[DatabaseIdentifier:12020745] Mondo:0004992
dbId	9699529
disease	[Disease:1500689] cancer
displayName	midostaurin-sensitive FLT3 mutants [plasma membrane]
hasMember	[Complex:R-HSA-9699476] FLT3 L610_E611insLKWEFPRENL dimer [plasma membrane] - Homo sapiens [Complex:R-HSA-9699483] FLT3 E596_Y597insRTDFRE dimer [plasma membrane] - Homo sapiens [Complex:R-HSA-9699489] FLT3 E611_F612insGDNEYFYVDFREYEYDLKWEFPRENLE dimer [plasma membrane] - Homo sapiens [Complex:R-HSA-9692031] FLT3 Y572C dimer [plasma membrane] - Homo sapiens [Complex:R-HSA-9691119] FLT3 V592G dimer [plasma membrane] - Homo sapiens [Complex:R-HSA-9699494] FLT3 F621L dimer [plasma membrane] - Homo sapiens [Complex:R-HSA-9695762] FLT3 F691L dimer [plasma membrane] - Homo sapiens [Complex:R-HSA-9692030] FLT3 R834Q dimer [plasma membrane] - Homo sapiens [Complex:R-HSA-9682330] FLT3 D835A dimer [plasma membrane] - Homo sapiens [Complex:R-HSA-9682332] FLT3 D835E dimer [plasma membrane] - Homo sapiens [Complex:R-HSA-9682341] FLT3 D835H dimer [plasma membrane] - Homo sapiens [Complex:R-HSA-9682344] FLT3 D835N dimer [plasma membrane] - Homo sapiens [Complex:R-HSA-9682347] FLT3 D835V dimer [plasma membrane] - Homo sapiens [Complex:R-HSA-9682356] FLT3 D835Y dimer [plasma membrane] - Homo sapiens [Complex:R-HSA-9695757] FLT3 D835del dimer [plasma membrane] - Homo sapiens [Complex:R-HSA-9695759] FLT3 I836del dimer [plasma membrane] - Homo sapiens [Complex:R-HSA-9699491] FLT3 Y842C dimer [plasma membrane] - Homo sapiens [Complex:R-HSA-9699477] FLT3 Y842H dimer [plasma membrane] - Homo sapiens [Complex:R-HSA-9702911] FLT3 A848P dimer [plasma membrane] - Homo sapiens
inDisease	true
literatureReference	[LiteratureReference:9699340] Metabolic alterations and drug sensitivity of tyrosine kinase inhibitor resistant leukemia cells with a FLT3/ITD mutation [LiteratureReference:9699345] Mutations of FLT3/ITD confer resistance to multiple tyrosine kinase inhibitors [LiteratureReference:9699384] The secondary FLT3-ITD F691L mutation induces resistance to AC220 in FLT3-ITD+ AML but retains in vitro sensitivity to PKC412 and Sunitinib [LiteratureReference:9699385] Uniform sensitivity of FLT3 activation loop mutants to the tyrosine kinase inhibitor midostaurin [LiteratureReference:9702875] Identification of a secondary FLT3/A848P mutation in a patient with FLT3-ITD-positive blast phase CMML and response to sunitinib and sorafenib [LiteratureReference:9699271] Emergence of polyclonal FLT3 tyrosine kinase domain mutations during sequential therapy with sorafenib and sunitinib in FLT3-ITD-positive acute myeloid leukemia [LiteratureReference:9691838] Identification of driver and passenger mutations of FLT3 by high-throughput DNA sequence analysis and functional assessment of candidate alleles [LiteratureReference:9702890] The effects of lestaurtinib (CEP701) and PKC412 on primary AML blasts: the induction of cytotoxicity varies with dependence on FLT3 signaling in both FLT3-mutated and wild-type cases [LiteratureReference:9702954] FLT3 activating mutations display differential sensitivity to multiple tyrosine kinase inhibitors
maxDepth	3
memberOf	[DefinedSet:R-HSA-9702522] type I TKI sensitive FLT3 mutants [plasma membrane] - Homo sapiens
modified	[InstanceEdit:9703028] Rothfels, Karen, 2020-10-03
name	midostaurin-sensitive FLT3 mutants
schemaClass	DefinedSet
species	[Species:48887] Homo sapiens
stId	R-HSA-9699529

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[DefinedSet:R-HSA-9702522] type I TKI sensitive FLT3 mutants [plasma membrane]

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