Reactome | p-6Y FLT3 E611_F612insGDNEYFYVDFREYEYDLKWEFPRENLE [plasma membrane]

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p-6Y FLT3 E611_F612insGDNEYFYVDFREYEYDLKWEFPRENLE [plasma membrane] Show undefined attributes

compartment	[Compartment:876] plasma membrane
componentOf	[Complex:R-HSA-9699487] p-6Y FLT3 E611_F612insGDNEYFYVDFREYEYDLKWEFPRENLE dimer [plasma membrane] - Homo sapiens [Complex:R-HSA-9699487] p-6Y FLT3 E611_F612insGDNEYFYVDFREYEYDLKWEFPRENLE dimer [plasma membrane] - Homo sapiens
created	[InstanceEdit:9699450] Rothfels, Karen, 2020-09-14
crossReference	[DatabaseIdentifier:12020776] Mondo:0018874
dbId	9699446
disease	[Disease:1500689] cancer [Disease:9630839] acute myeloid leukemia
displayName	p-6Y FLT3 E611_F612insGDNEYFYVDFREYEYDLKWEFPRENLE [plasma membrane]
endCoordinate	993
hasModifiedResidue	[FragmentReplacedModification:9699447] Replacement of residues 610 to 611 by EGDNEYFYVDFREYEYDLKWEFPRENLEF [ModifiedResidue:9604760] O4'-phospho-L-tyrosine at 589 [ModifiedResidue:9604750] O4'-phospho-L-tyrosine at 591 [ModifiedResidue:9604772] O4'-phospho-L-tyrosine at 599 [ModifiedResidue:9604762] O4'-phospho-L-tyrosine at 768 [ModifiedResidue:9604765] O4'-phospho-L-tyrosine at 955 [ModifiedResidue:9604743] O4'-phospho-L-tyrosine at 969
inDisease	true
literatureReference	[LiteratureReference:9699329] Inhibition of the transforming activity of FLT3 internal tandem duplication mutants from AML patients by a tyrosine kinase inhibitor
maxDepth	1
modified	[InstanceEdit:9832502] Orlic-Milacic, Marija, 2023-04-01
name	p-6Y FLT3 E611_F612insGDNEYFYVDFREYEYDLKWEFPRENLE ITD2
referenceEntity	[ReferenceGeneProduct:uniprot:P36888] UniProt:P36888 FLT3
referenceType	ReferenceGeneProduct
schemaClass	EntityWithAccessionedSequence
species	[Species:48887] Homo sapiens
stId	R-HSA-9699446
startCoordinate	27
updateTrackers	[UpdateTracker:9905739] Update Tracker - [EntityWithAccessionedSequence:9699446] p-6Y FLT3 E611_F612insGDNEYFYVDFREYEYDLKWEFPRENLE [plasma membrane] - v85:[removeHasModifiedResidue]

Referrals

(updatedInstance)	[UpdateTracker:9905739] Update Tracker - [EntityWithAccessionedSequence:9699446] p-6Y FLT3 E611_F612insGDNEYFYVDFREYEYDLKWEFPRENLE [plasma membrane] - v85:[removeHasModifiedResidue]
(hasComponent)	[Complex:R-HSA-9699487] p-6Y FLT3 E611_F612insGDNEYFYVDFREYEYDLKWEFPRENLE dimer [plasma membrane]

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