Reactome | FLT3 Y842C [plasma membrane]

Schema > EntityWithAccessionedSequence > Entries

compartment	[Compartment:876] plasma membrane
componentOf	[Complex:R-HSA-9699491] FLT3 Y842C dimer [plasma membrane] - Homo sapiens
created	[InstanceEdit:9699450] Rothfels, Karen, 2020-09-14
crossReference	[DatabaseIdentifier:9699442] COSMIC:COSV54044083
dbId	9699435
disease	[Disease:1500689] cancer [Disease:9630839] acute myeloid leukemia
displayName	FLT3 Y842C [plasma membrane]
endCoordinate	993
hasModifiedResidue	[ReplacedResidue:9699441] L-tyrosine 842 replaced with L-cysteine
inDisease	true
literatureReference	[LiteratureReference:9699345] Mutations of FLT3/ITD confer resistance to multiple tyrosine kinase inhibitors
memberOf	[DefinedSet:R-HSA-9699528] sunitinib-resistant FLT3 mutants [plasma membrane] - Homo sapiens [DefinedSet:R-HSA-9699525] quizartinib-resistant FLT3 mutants [plasma membrane] - Homo sapiens [DefinedSet:R-HSA-9699530] sorafenib-resistant FLT3 mutants [plasma membrane] - Homo sapiens [CandidateSet:R-HSA-9682396] kinase domain mutants of FLT3 [plasma membrane] - Homo sapiens
name	FLT3 Y842C
referenceEntity	[ReferenceGeneProduct:54914] UniProt:P36888 FLT3
referenceType	ReferenceGeneProduct
schemaClass	EntityWithAccessionedSequence
species	[Species:48887] Homo sapiens
stId	R-HSA-9699435
startCoordinate	27

(hasMember)	[DefinedSet:R-HSA-9699528] sunitinib-resistant FLT3 mutants [plasma membrane] [DefinedSet:R-HSA-9699530] sorafenib-resistant FLT3 mutants [plasma membrane] [DefinedSet:R-HSA-9699525] quizartinib-resistant FLT3 mutants [plasma membrane] [CandidateSet:R-HSA-9682396] kinase domain mutants of FLT3 [plasma membrane]
(hasComponent)	[Complex:R-HSA-9699491] FLT3 Y842C dimer [plasma membrane]