Reactome | p-6Y-FLT3 V592_E598dup [plasma membrane]

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p-6Y-FLT3 V592_E598dup [plasma membrane] Show undefined attributes

compartment	[Compartment:876] plasma membrane
componentOf	[Complex:R-HSA-9699496] p-6Y FLT3 E598_Y599insVDFREYE dimer [plasma membrane] - Homo sapiens [Complex:R-HSA-9699496] p-6Y FLT3 E598_Y599insVDFREYE dimer [plasma membrane] - Homo sapiens
created	[InstanceEdit:9699450] Rothfels, Karen, 2020-09-14
crossReference	[DatabaseIdentifier:12020776] Mondo:0018874
dbId	9699429
disease	[Disease:1500689] cancer [Disease:9630839] acute myeloid leukemia
displayName	p-6Y-FLT3 V592_E598dup [plasma membrane]
endCoordinate	993
hasModifiedResidue	[FragmentInsertionModification:9699444] Insertion of residues 592 to 598 at 599 from UniProt:P36888 FLT3 [ModifiedResidue:9604760] O4'-phospho-L-tyrosine at 589 [ModifiedResidue:9604750] O4'-phospho-L-tyrosine at 591 [ModifiedResidue:9604772] O4'-phospho-L-tyrosine at 599 [ModifiedResidue:9604762] O4'-phospho-L-tyrosine at 768 [ModifiedResidue:9604765] O4'-phospho-L-tyrosine at 955 [ModifiedResidue:9604743] O4'-phospho-L-tyrosine at 969
inDisease	true
literatureReference	[LiteratureReference:9699292] FLT3 mutations in acute myeloid leukemia cell lines [LiteratureReference:9699248] Crenolanib is a potent inhibitor of FLT3 with activity against resistance-conferring point mutants
maxDepth	1
modified	[InstanceEdit:9832457] Orlic-Milacic, Marija, 2023-04-01
name	p-6Y-FLT3 V592_E598dup MOLM-14
referenceEntity	[ReferenceGeneProduct:uniprot:P36888] UniProt:P36888 FLT3
referenceType	ReferenceGeneProduct
schemaClass	EntityWithAccessionedSequence
species	[Species:48887] Homo sapiens
stId	R-HSA-9699429
startCoordinate	27
updateTrackers	[UpdateTracker:9905420] Update Tracker - [EntityWithAccessionedSequence:9699429] p-6Y-FLT3 V592_E598dup [plasma membrane] - v85:[modifyName]

Referrals

(updatedInstance)	[UpdateTracker:9905420] Update Tracker - [EntityWithAccessionedSequence:9699429] p-6Y-FLT3 V592_E598dup [plasma membrane] - v85:[modifyName]
(hasComponent)	[Complex:R-HSA-9699496] p-6Y FLT3 E598_Y599insVDFREYE dimer [plasma membrane]

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