Reactome | FLT3 E596_Y597insRTDFRE [plasma membrane]

Schema > EntityWithAccessionedSequence > Entries

compartment	[Compartment:876] plasma membrane
componentOf	[Complex:R-HSA-9699483] FLT3 E596_Y597insRTDFRE dimer [plasma membrane] - Homo sapiens
created	[InstanceEdit:9699450] Rothfels, Karen, 2020-09-14
dbId	9699428
disease	[Disease:1500689] cancer [Disease:9630839] acute myeloid leukemia
displayName	FLT3 E596_Y597insRTDFRE [plasma membrane]
endCoordinate	993
hasModifiedResidue	[FragmentReplacedModification:9699418] Replacement of residues 596 to 597 by ERTDFREY
inDisease	true
literatureReference	[LiteratureReference:9699329] Inhibition of the transforming activity of FLT3 internal tandem duplication mutants from AML patients by a tyrosine kinase inhibitor
memberOf	[DefinedSet:R-HSA-9699532] sunitinib-sensitive FLT3 mutants [plasma membrane] - Homo sapiens [DefinedSet:R-HSA-9699522] sorafenib-sensitive FLT3 mutants [plasma membrane] - Homo sapiens [CandidateSet:R-HSA-9691152] juxtamembrane domain mutants of FLT3 [plasma membrane] - Homo sapiens
modified	[InstanceEdit:9832487] Orlic-Milacic, Marija, 2023-04-01
name	FLT3 E596_Y597insRTDFRE ITD1
referenceEntity	[ReferenceGeneProduct:54914] UniProt:P36888 FLT3
referenceType	ReferenceGeneProduct
schemaClass	EntityWithAccessionedSequence
species	[Species:48887] Homo sapiens
stId	R-HSA-9699428
startCoordinate	27

(hasMember)	[DefinedSet:R-HSA-9699532] sunitinib-sensitive FLT3 mutants [plasma membrane] [DefinedSet:R-HSA-9699522] sorafenib-sensitive FLT3 mutants [plasma membrane] [CandidateSet:R-HSA-9691152] juxtamembrane domain mutants of FLT3 [plasma membrane]
(hasComponent)	[Complex:R-HSA-9699483] FLT3 E596_Y597insRTDFRE dimer [plasma membrane]

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