Reactome | FLT3 ITD- and STAT5-dependent NOX4 gene expression

Schema > BlackBoxEvent > Entries

FLT3 ITD- and STAT5-dependent NOX4 gene expression Show undefined attributes

authored	[InstanceEdit:9706566] Rothfels, Karen, 2020-11-06
category	omitted
compartment	[Compartment:7660] nucleoplasm [Compartment:876] plasma membrane
created	[InstanceEdit:9698733] Rothfels, Karen, 2020-08-28
crossReference	[DatabaseIdentifier:12020776] Mondo:0018874
dbId	9698762
disease	[Disease:9630839] acute myeloid leukemia [Disease:1500689] cancer
displayName	FLT3 ITD- and STAT5-dependent NOX4 gene expression
edited	[InstanceEdit:9706566] Rothfels, Karen, 2020-11-06
eventOf	[Pathway:R-HSA-9702518] STAT5 activation downstream of FLT3 ITD mutants - Homo sapiens [Pathway:R-HSA-9703465] Signaling by FLT3 fusion proteins - Homo sapiens
followingEvent	[Reaction:R-HSA-9698758] FLT3 ITD- and NOX4-dependent H2O2 production - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-9698757] NOX4 gene [nucleoplasm]
isChimeric	false
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:9697866] Protein-tyrosine phosphatase DEP-1 controls receptor tyrosine kinase FLT3 signaling [LiteratureReference:9698765] Cell transformation by FLT3 ITD in acute myeloid leukemia involves oxidative inactivation of the tumor suppressor protein-tyrosine phosphatase DEP-1/ PTPRJ [LiteratureReference:9698736] Loss of DEP-1 (Ptprj) promotes myeloproliferative disease in FLT3-ITD acute myeloid leukemia [LiteratureReference:9698748] NOX-driven ROS formation in cell transformation of FLT3-ITD-positive AML [LiteratureReference:9698776] NOX4-driven ROS formation mediates PTP inactivation and cell transformation in FLT3ITD-positive AML cells
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	FLT3 ITD- and STAT5-dependent NOX4 gene expression
output	[EntityWithAccessionedSequence:R-HSA-5212694] NOX4 [plasma membrane]
precedingEvent	[Reaction:R-HSA-9698754] p-STAT5 binds the NOX4 promoter - Homo sapiens
regulatedBy	[PositiveGeneExpressionRegulation:9698743] Positive gene expression regulation by 'NOX4 gene:p-STAT5 [nucleoplasm]'
releaseDate	2020-12-08
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9706568] Kazi, Julhash U, 2020-11-06
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-9698762
summation	[Summation:9698759] NOX4 expression is upregulated in a FLT3 ITD- and STAT5-depe...

Referrals

(hasEvent)	[Pathway:R-HSA-9703465] Signaling by FLT3 fusion proteins [Pathway:R-HSA-9702518] STAT5 activation downstream of FLT3 ITD mutants
(precedingEvent)	[Reaction:R-HSA-9698758] FLT3 ITD- and NOX4-dependent H2O2 production

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