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Schema
>
BlackBoxEvent
>
Entries
FLT3 ITD- and STAT5-dependent NOX4 gene expression
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authored
[InstanceEdit:9706566] Rothfels, Karen, 2020-11-06
category
omitted
compartment
[Compartment:7660] nucleoplasm
[Compartment:876] plasma membrane
created
[InstanceEdit:9698733] Rothfels, Karen, 2020-08-28
dbId
9698762
disease
[Disease:9630839] acute myeloid leukemia
[Disease:1500689] cancer
displayName
FLT3 ITD- and STAT5-dependent NOX4 gene expression
edited
[InstanceEdit:9706566] Rothfels, Karen, 2020-11-06
eventOf
[Pathway:R-HSA-9702518] STAT5 activation downstream of FLT3 ITD mutants - Homo sapiens
[Pathway:R-HSA-9703465] Signaling by FLT3 fusion proteins - Homo sapiens
followingEvent
[Reaction:R-HSA-9698758] FLT3 ITD- and NOX4-dependent H2O2 production - Homo sapiens
input
[EntityWithAccessionedSequence:R-HSA-9698757] NOX4 gene [nucleoplasm]
isChimeric
false
isInDisease
true
isInferred
false
literatureReference
[LiteratureReference:9697866] Protein-tyrosine phosphatase DEP-1 controls receptor tyrosine kinase FLT3 signaling
[LiteratureReference:9698765] Cell transformation by FLT3 ITD in acute myeloid leukemia involves oxidative inactivation of the tumor suppressor protein-tyrosine phosphatase DEP-1/ PTPRJ
[LiteratureReference:9698736] Loss of DEP-1 (Ptprj) promotes myeloproliferative disease in
FLT3
-ITD acute myeloid leukemia
[LiteratureReference:9698748] NOX-driven ROS formation in cell transformation of FLT3-ITD-positive AML
[LiteratureReference:9698776] NOX4-driven ROS formation mediates PTP inactivation and cell transformation in FLT3ITD-positive AML cells
modified
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name
FLT3 ITD- and STAT5-dependent NOX4 gene expression
output
[EntityWithAccessionedSequence:R-HSA-5212694] NOX4 [plasma membrane]
precedingEvent
[Reaction:R-HSA-9698754] p-STAT5 binds the NOX4 promoter - Homo sapiens
regulatedBy
[PositiveGeneExpressionRegulation:9698743] Positive gene expression regulation by 'NOX4 gene:p-STAT5 [nucleoplasm]'
releaseDate
2020-12-08
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:9706568] Kazi, Julhash U, 2020-11-06
schemaClass
BlackBoxEvent
species
[Species:48887] Homo sapiens
stId
R-HSA-9698762
summation
[Summation:9698759] NOX4 expression is upregulated in a FLT3 ITD- and STAT5-depe...
Referrals
(hasEvent)
[Pathway:R-HSA-9703465] Signaling by FLT3 fusion proteins
[Pathway:R-HSA-9702518] STAT5 activation downstream of FLT3 ITD mutants
(precedingEvent)
[Reaction:R-HSA-9698758] FLT3 ITD- and NOX4-dependent H2O2 production
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