FLT3 ITD- and STAT5-dependent NOX4 gene expression

Stable Identifier
R-HSA-9698762
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

NOX4 expression is upregulated in a FLT3 ITD- and STAT5-dependent manner relative to levels in wild type cells. NOX4 expression increases production of reactive oxygen species, resulting in the inhibition of the catalytic site of the FLT3 negative regulator PTPRJ (also known as DEP1). As a consequence, FLT3 ITD mutants show enhance signaling, proliferation and colony forming ability (Arora et al, 2011; Godfrey et al, 2012; Kesinsky et al, 2015; Jayavelu et al, 2016; reviewed in Jayavelu et al, 2016).

Literature References
PubMed ID Title Journal Year
22438257 Cell transformation by FLT3 ITD in acute myeloid leukemia involves oxidative inactivation of the tumor suppressor protein-tyrosine phosphatase DEP-1/ PTPRJ

Godfrey, R, Arora, D, Bauer, R, Stopp, S, Müller, JP, Heinrich, T, Böhmer, SA, Dagnell, M, Schnetzke, U, Scholl, S, Östman, A, Böhmer, FD

Blood 2012
27666490 NOX-driven ROS formation in cell transformation of FLT3-ITD-positive AML

Jayavelu, AK, Moloney, JN, Böhmer, FD, Cotter, TG

Exp. Hematol. 2016
26308771 NOX4-driven ROS formation mediates PTP inactivation and cell transformation in FLT3ITD-positive AML cells

Jayavelu, AK, Müller, JP, Bauer, R, Böhmer, SA, Lässig, J, Cerny-Reiterer, S, Sperr, WR, Valent, P, Maurer, B, Moriggl, R, Schröder, K, Shah, AM, Fischer, M, Scholl, S, Barth, J, Oellerich, T, Berg, T, Serve, H, Frey, S, Fischer, T, Heidel, FH, Böhmer, FD

Leukemia 2016
21262971 Protein-tyrosine phosphatase DEP-1 controls receptor tyrosine kinase FLT3 signaling

Arora, D, Stopp, S, Böhmer, SA, Schons, J, Godfrey, R, Masson, K, Razumovskaya, E, Rönnstrand, L, Tänzer, S, Bauer, R, Böhmer, FD, Müller, JP

J. Biol. Chem. 2011
29880609 Loss of DEP-1 (Ptprj) promotes myeloproliferative disease in FLT3-ITD acute myeloid leukemia

Kresinsky, A, Bauer, R, Schnöder, TM, Berg, T, Meyer, D, Ast, V, König, R, Serve, H, Heidel, FH, Böhmer, FD, Müller, JP

Haematologica 2018
Participants
Participant Of
This event is regulated
Disease
Name Identifier Synonyms
acute myeloid leukemia 9119 Leukemia, Myelocytic, acute, acute myeloblastic leukemia, acute myelogenous leukemia, AML - acute Myeloid Leukemia
cancer 162 malignant tumor, malignant neoplasm, primary cancer
Authored
Reviewed
Created
Cite Us!