Reactome | PTPN11:p-STAT5 translocates to nucleus downstream of mutant FLT3

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PTPN11:p-STAT5 translocates to nucleus downstream of mutant FLT3 Show undefined attributes

authored	[InstanceEdit:9706566] Rothfels, Karen, 2020-11-06
category	omitted
compartment	[Compartment:876] plasma membrane [Compartment:7660] nucleoplasm
created	[InstanceEdit:9698015] Rothfels, Karen, 2020-08-21
crossReference	[DatabaseIdentifier:12020745] Mondo:0004992
dbId	9698016
disease	[Disease:1500689] cancer
displayName	PTPN11:p-STAT5 translocates to nucleus downstream of mutant FLT3
edited	[InstanceEdit:9706566] Rothfels, Karen, 2020-11-06
eventOf	[Pathway:R-HSA-9702518] STAT5 activation downstream of FLT3 ITD mutants - Homo sapiens
followingEvent	[Reaction:R-HSA-9698021] PTPN11:p-STAT5 binds BCL2L1 promoter - Homo sapiens
input	[Complex:R-HSA-9697990] PTPN11:p-STAT5 [cytosol]
isChimeric	false
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:9604970] The protein tyrosine phosphatase, Shp2, positively contributes to FLT3-ITD-induced hematopoietic progenitor hyperproliferation and malignant disease in vivo
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	PTPN11:p-STAT5 translocates to nucleus downstream of mutant FLT3
output	[Complex:R-HSA-9697993] PTPN11:p-STAT5 [nucleoplasm]
precedingEvent	[Reaction:R-HSA-9698013] PTPN11:p-STAT5 dissociates from mutant FLT3 - Homo sapiens
releaseDate	2020-12-08
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9706568] Kazi, Julhash U, 2020-11-06
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-9698016
summation	[Summation:9697920] PTPN11:p-STAT5 has been shown to bind to gamma-interferon ac...

Referrals

(precedingEvent)	[Reaction:R-HSA-9698021] PTPN11:p-STAT5 binds BCL2L1 promoter
(hasEvent)	[Pathway:R-HSA-9702518] STAT5 activation downstream of FLT3 ITD mutants

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