PTPN11:p-STAT5 translocates to nucleus downstream of mutant FLT3

Stable Identifier
R-HSA-9698016
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
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PTPN11:p-STAT5 has been shown to bind to gamma-interferon activation sites (GAS) in the promoter of BCL2L1 downstream of FLT3-ITD signaling, suggesting that this complex translocates from the cytosol to the nucleus (Nabinger et al, 2013; reviewed in Murphy and Rani, 2015).

Literature References
PubMed ID Title Journal Year
23103841 The protein tyrosine phosphatase, Shp2, positively contributes to FLT3-ITD-induced hematopoietic progenitor hyperproliferation and malignant disease in vivo

Nabinger, SC, Li, XJ, Ramdas, B, He, Y, Zhang, X, Zeng, L, Richine, B, Bowling, JD, Fukuda, S, Goenka, S, Liu, Z, Feng, GS, Yu, M, Sandusky, GE, Boswell, HS, Zhang, ZY, Kapur, R, Chan, RJ

Leukemia 2013
Participants
Participant Of
Disease
Name Identifier Synonyms
cancer 162 malignant tumor, malignant neoplasm, primary cancer
Authored
Reviewed
Created
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