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Schema
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Reaction
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Entries
FLT3 ITD mutants phosphorylate STAT5
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authored
[InstanceEdit:9706566] Rothfels, Karen, 2020-11-06
catalystActivity
[CatalystActivity:9697998] protein tyrosine kinase activity of p-6Y FLT3 ITD mutant dimers:GRB2:p-Y GAB2:PTPN11:STAT5 [plasma membrane]
category
transition
compartment
[Compartment:876] plasma membrane
created
[InstanceEdit:9698006] Rothfels, Karen, 2020-08-21
dbId
9698005
disease
[Disease:1500689] cancer
displayName
FLT3 ITD mutants phosphorylate STAT5
edited
[InstanceEdit:9706566] Rothfels, Karen, 2020-11-06
entityFunctionalStatus
[EntityFunctionalStatus:9698192] gain_of_function of p-6Y FLT3 ITD mutant dimers:GRB2:p-Y GAB2:PTPN11:STAT5 [plasma membrane]
eventOf
[Pathway:R-HSA-9702518] STAT5 activation downstream of FLT3 ITD mutants - Homo sapiens
followingEvent
[Reaction:R-HSA-9698013] PTPN11:p-STAT5 dissociates from mutant FLT3 - Homo sapiens
[Reaction:R-HSA-9698029] p-STAT5 dissociates from mutant FLT3 - Homo sapiens
input
2 ×
[SimpleEntity:R-ALL-113592] ATP [cytosol]
[Complex:R-HSA-9697982] p-6Y FLT3 ITD mutant dimers:GRB2:p-Y GAB2:PTPN11:STAT5 [plasma membrane]
isChimeric
false
isInDisease
true
isInferred
false
literatureReference
[LiteratureReference:9649423] Flt3 mutations from patients with acute myeloid leukemia induce transformation of 32D cells mediated by the Ras and STAT5 pathways
[LiteratureReference:9697896] Tandem-duplicated Flt3 constitutively activates STAT5 and MAP kinase and introduces autonomous cell growth in IL-3-dependent cell lines
[LiteratureReference:9649425] Roles of tyrosine 589 and 591 in STAT5 activation and transformation mediated by FLT3-ITD
[LiteratureReference:9697850] Overexpression and constitutive activation of FLT3 induces STAT5 activation in primary acute myeloid leukemia blast cells
[LiteratureReference:9697800] Activation mechanisms of STAT5 by oncogenic Flt3-ITD
[LiteratureReference:9697873] SRC is a signaling mediator in FLT3-ITD- but not in FLT3-TKD-positive AML
[LiteratureReference:9697836] FES kinases are required for oncogenic FLT3 signaling
[LiteratureReference:9697839] FMS-like Tyrosine Kinase 3/FLT3: From Basic Science to Clinical Implications
[LiteratureReference:9697902] The role of SRC family kinases in FLT3 signaling
[LiteratureReference:9697887] Suppression of myeloid transcription factors and induction of STAT response genes by AML-specific Flt3 mutations
[LiteratureReference:9697845] Flt3 mutation activates p21WAF1/CIP1 gene expression through the action of STAT5
[LiteratureReference:9697855] Pim-1 is up-regulated by constitutively activated FLT3 and plays a role in FLT3-mediated cell survival
[LiteratureReference:9697821] CDC25A governs proliferation and differentiation of FLT3-ITD acute myeloid leukemia
[LiteratureReference:9604970] The protein tyrosine phosphatase, Shp2, positively contributes to FLT3-ITD-induced hematopoietic progenitor hyperproliferation and malignant disease in vivo
modified
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name
FLT3 ITD mutants phosphorylate STAT5
normalReaction
[Reaction:R-HSA-9645137] Activator phosphorylates STAT5
output
2 ×
[SimpleEntity:R-ALL-29370] ADP [cytosol]
[Complex:R-HSA-9697985] p-6Y FLT3 ITD mutant dimers:GRB2:p-Y GAB2:PTPN11:p-STAT5 [plasma membrane]
precedingEvent
[Reaction:R-HSA-9698007] FLT3 ITD mutants bind STAT5 through GAB2:PTPN11 - Homo sapiens
releaseDate
2020-12-08
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:9706568] Kazi, Julhash U, 2020-11-06
schemaClass
Reaction
species
[Species:48887] Homo sapiens
stId
R-HSA-9698005
summation
[Summation:9697928] STAT5 is phosphorylated downstream of FLT3 ITD mutants (Haya...
Referrals
(precedingEvent)
[Reaction:R-HSA-9698013] PTPN11:p-STAT5 dissociates from mutant FLT3
[Reaction:R-HSA-9698029] p-STAT5 dissociates from mutant FLT3
(hasEvent)
[Pathway:R-HSA-9702518] STAT5 activation downstream of FLT3 ITD mutants
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