Reactome | FLT3 F590_F605dup [plasma membrane]

Schema > EntityWithAccessionedSequence > Entries

compartment	[Compartment:876] plasma membrane
componentOf	[Complex:R-HSA-9697960] FLT3 Y589_F590insFYVDFREYEYDLKWEF dimer [plasma membrane] - Homo sapiens [Complex:R-HSA-9697960] FLT3 Y589_F590insFYVDFREYEYDLKWEF dimer [plasma membrane] - Homo sapiens
created	[InstanceEdit:9697940] Rothfels, Karen, 2020-08-21
crossReference	[DatabaseIdentifier:12020776] Mondo:0018874
dbId	9697939
disease	[Disease:1500689] cancer [Disease:9630839] acute myeloid leukemia
displayName	FLT3 F590_F605dup [plasma membrane]
endCoordinate	993
hasModifiedResidue	[FragmentInsertionModification:9697936] Insertion of residues 590 to 605 at 589 from UniProt:P36888 FLT3
inDisease	true
literatureReference	[LiteratureReference:9697896] Tandem-duplicated Flt3 constitutively activates STAT5 and MAP kinase and introduces autonomous cell growth in IL-3-dependent cell lines
maxDepth	1
memberOf	[CandidateSet:R-HSA-9691152] juxtamembrane domain mutants of FLT3 [plasma membrane] - Homo sapiens
modified	[InstanceEdit:9832467] Orlic-Milacic, Marija, 2023-04-01
name	FLT3 F590_F605dup Mut2
referenceEntity	[ReferenceGeneProduct:uniprot:P36888] UniProt:P36888 FLT3
referenceType	ReferenceGeneProduct
schemaClass	EntityWithAccessionedSequence
species	[Species:48887] Homo sapiens
stId	R-HSA-9697939
startCoordinate	27
updateTrackers	[UpdateTracker:9905518] Update Tracker - [EntityWithAccessionedSequence:9697939] FLT3 F590_F605dup [plasma membrane] - v85:[modifyName]

(updatedInstance)	[UpdateTracker:9905518] Update Tracker - [EntityWithAccessionedSequence:9697939] FLT3 F590_F605dup [plasma membrane] - v85:[modifyName]
(hasMember)	[CandidateSet:R-HSA-9691152] juxtamembrane domain mutants of FLT3 [plasma membrane]
(hasComponent)	[Complex:R-HSA-9697960] FLT3 Y589_F590insFYVDFREYEYDLKWEF dimer [plasma membrane]

Cite Us!