Reactome | FLT3 Y591_V592insVDFREDREHH [plasma membrane]

Schema > EntityWithAccessionedSequence > Entries

compartment	[Compartment:876] plasma membrane
componentOf	[Complex:R-HSA-9696078] FLT3 Y591_V592insVDFREDREHH dimer [plasma membrane] - Homo sapiens [Complex:R-HSA-9696078] FLT3 Y591_V592insVDFREDREHH dimer [plasma membrane] - Homo sapiens
created	[InstanceEdit:9696040] Rothfels, Karen, 2020-07-17
crossReference	[DatabaseIdentifier:12020776] Mondo:0018874
dbId	9696043
disease	[Disease:1500689] cancer [Disease:9630839] acute myeloid leukemia
displayName	FLT3 Y591_V592insVDFREDREHH [plasma membrane]
endCoordinate	993
hasModifiedResidue	[FragmentReplacedModification:9696019] Replacement of residues 591 to 592 by YVDFRREDREHHV
inDisease	true
literatureReference	[LiteratureReference:9649423] Flt3 mutations from patients with acute myeloid leukemia induce transformation of 32D cells mediated by the Ras and STAT5 pathways
maxDepth	1
memberOf	[CandidateSet:R-HSA-9691152] juxtamembrane domain mutants of FLT3 [plasma membrane] - Homo sapiens
modified	[InstanceEdit:9832478] Orlic-Milacic, Marija, 2023-04-01
name	FLT3 Y591_V592insVDFREDREHH ITD4
referenceEntity	[ReferenceGeneProduct:uniprot:P36888] UniProt:P36888 FLT3
referenceType	ReferenceGeneProduct
schemaClass	EntityWithAccessionedSequence
species	[Species:48887] Homo sapiens
stId	R-HSA-9696043
startCoordinate	27
updateTrackers	[UpdateTracker:9905431] Update Tracker - [EntityWithAccessionedSequence:9696043] FLT3 Y591_V592insVDFREDREHH [plasma membrane] - v85:[removeHasModifiedResidue]

(updatedInstance)	[UpdateTracker:9905431] Update Tracker - [EntityWithAccessionedSequence:9696043] FLT3 Y591_V592insVDFREDREHH [plasma membrane] - v85:[removeHasModifiedResidue]
(hasMember)	[CandidateSet:R-HSA-9691152] juxtamembrane domain mutants of FLT3 [plasma membrane]
(hasComponent)	[Complex:R-HSA-9696078] FLT3 Y591_V592insVDFREDREHH dimer [plasma membrane]

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