Reactome | p-6Y-FLT3 R595_L601dup [plasma membrane]

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p-6Y-FLT3 R595_L601dup [plasma membrane] Show undefined attributes

compartment	[Compartment:876] plasma membrane
componentOf	[Complex:R-HSA-9696095] p-6Y-FLT3 R595_L601dup dimer [plasma membrane] - Homo sapiens [Complex:R-HSA-9696095] p-6Y-FLT3 R595_L601dup dimer [plasma membrane] - Homo sapiens
created	[InstanceEdit:9696040] Rothfels, Karen, 2020-07-17
crossReference	[DatabaseIdentifier:12020776] Mondo:0018874 [DatabaseIdentifier:9832470] COSMIC:COSV54045432
dbId	9696035
deleted	[Deleted:9832475] Deletion of instance: 9696049
disease	[Disease:1500689] cancer [Disease:9630839] acute myeloid leukemia
displayName	p-6Y-FLT3 R595_L601dup [plasma membrane]
endCoordinate	993
hasModifiedResidue	[ModifiedResidue:9604760] O4'-phospho-L-tyrosine at 589 [ModifiedResidue:9604750] O4'-phospho-L-tyrosine at 591 [ModifiedResidue:9604772] O4'-phospho-L-tyrosine at 599 [ModifiedResidue:9604762] O4'-phospho-L-tyrosine at 768 [ModifiedResidue:9604765] O4'-phospho-L-tyrosine at 955 [ModifiedResidue:9604743] O4'-phospho-L-tyrosine at 969 [FragmentInsertionModification:9696029] Insertion of residues 595 to 601 at 602 from UniProt:P36888 FLT3
inDisease	true
literatureReference	[LiteratureReference:9649423] Flt3 mutations from patients with acute myeloid leukemia induce transformation of 32D cells mediated by the Ras and STAT5 pathways [LiteratureReference:9696007] FLT3 internal tandem duplication mutations associated with human acute myeloid leukemias induce myeloproliferative disease in a murine bone marrow transplant model
maxDepth	1
modified	[InstanceEdit:9832472] Orlic-Milacic, Marija, 2023-04-01
name	p-6Y-FLT3 R595_L601dup ITD3 W51
referenceEntity	[ReferenceGeneProduct:uniprot:P36888] UniProt:P36888 FLT3
referenceType	ReferenceGeneProduct
schemaClass	EntityWithAccessionedSequence
species	[Species:48887] Homo sapiens
stId	R-HSA-9696035
startCoordinate	27
updateTrackers	[UpdateTracker:9905911] Update Tracker - [EntityWithAccessionedSequence:9696035] p-6Y-FLT3 R595_L601dup [plasma membrane] - v85:[addLiteratureReference, modifyName]

Referrals

(updatedInstance)	[UpdateTracker:9905911] Update Tracker - [EntityWithAccessionedSequence:9696035] p-6Y-FLT3 R595_L601dup [plasma membrane] - v85:[addLiteratureReference, modifyName]
(replacementInstances)	[Deleted:9832475] Deletion of instance: 9696049
(hasComponent)	[Complex:R-HSA-9696095] p-6Y-FLT3 R595_L601dup dimer [plasma membrane]

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