Reactome | FLT3 D839G [plasma membrane]

Schema > EntityWithAccessionedSequence > Entries

compartment	[Compartment:876] plasma membrane
componentOf	[Complex:R-HSA-9695763] FLT3 D839G dimer [plasma membrane] - Homo sapiens [Complex:R-HSA-9695763] FLT3 D839G dimer [plasma membrane] - Homo sapiens
created	[InstanceEdit:9695711] Rothfels, Karen, 2020-07-15
crossReference	[DatabaseIdentifier:12020776] Mondo:0018874 [DatabaseIdentifier:9695681] COSMIC:COSV54045448 [DatabaseIdentifier:9695695] COSMIC:COSM4606330
dbId	9695718
disease	[Disease:1500689] cancer [Disease:2317476] acute lymphocytic leukemia [Disease:9630839] acute myeloid leukemia
displayName	FLT3 D839G [plasma membrane]
endCoordinate	993
hasModifiedResidue	[ReplacedResidue:9695636] L-aspartic acid 839 replaced with glycine
inDisease	true
literatureReference	[LiteratureReference:9695648] Activity of ponatinib against clinically-relevant AC220-resistant kinase domain mutants of FLT3-ITD
maxDepth	1
memberOf	[CandidateSet:R-HSA-9682396] kinase domain mutants of FLT3 [plasma membrane] - Homo sapiens
name	FLT3 D839G STK-1
referenceEntity	[ReferenceGeneProduct:uniprot:P36888] UniProt:P36888 FLT3
referenceType	ReferenceGeneProduct
schemaClass	EntityWithAccessionedSequence
species	[Species:48887] Homo sapiens
stId	R-HSA-9695718
startCoordinate	27

(hasMember)	[CandidateSet:R-HSA-9682396] kinase domain mutants of FLT3 [plasma membrane]
(hasComponent)	[Complex:R-HSA-9695763] FLT3 D839G dimer [plasma membrane]

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