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Schema
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Reaction
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Entries
Small molecule inhibitor binds RIPK1, RIPK3
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authored
[InstanceEdit:9689635] Shamovsky, Veronica, 2020-05-21
category
binding
compartment
[Compartment:70101] cytosol
created
[InstanceEdit:9693949] Shamovsky, Veronica, 2020-07-08
dbId
9693978
displayName
Small molecule inhibitor binds RIPK1, RIPK3
edited
[InstanceEdit:9698642] Shamovsky, Veronica, 2020-08-28
eventOf
[Pathway:R-HSA-5675482] Regulation of necroptotic cell death - Homo sapiens
goBiologicalProcess
[GO_BiologicalProcess:9637490] negative regulation of programmed necrotic cell death
input
[Complex:R-HSA-5218862] RIPK1:RIPK3 [cytosol]
[DefinedSet:R-HSA-9694028] small molecule inhibitors of RIPK1, RIPK3 [cytosol]
isChimeric
false
isInDisease
false
isInferred
false
literatureReference
[LiteratureReference:9693961] Sorafenib tosylate inhibits directly necrosome complex formation and protects in mouse models of inflammation and tissue injury
[LiteratureReference:9694030] A cellular screen identifies ponatinib and pazopanib as inhibitors of necroptosis
maxDepth
1
modified
[InstanceEdit:11108703] Weiser, Joel, 2026-03-16
name
Small molecule inhibitor binds RIPK1, RIPK3
Sorafenib, pazopanib or ponatinib binds RIPK1, RIPK3
orthologousEvent
[Reaction:R-PFA-9693978] Small molecule inhibitor binds RIPK1, RIPK3 - Plasmodium falciparum
[Reaction:R-DDI-9693978] Small molecule inhibitor binds RIPK1, RIPK3 - Dictyostelium discoideum
[Reaction:R-SSC-9693978] Small molecule inhibitor binds RIPK1, RIPK3 - Sus scrofa
[Reaction:R-BTA-9693978] Small molecule inhibitor binds RIPK1, RIPK3 - Bos taurus
[Reaction:R-CFA-9693978] Small molecule inhibitor binds RIPK1, RIPK3 - Canis familiaris
[Reaction:R-RNO-9693978] Small molecule inhibitor binds RIPK1, RIPK3 - Rattus norvegicus
[Reaction:R-MMU-9693978] Small molecule inhibitor binds RIPK1, RIPK3 - Mus musculus
output
[Complex:R-HSA-9693943] RIPK1:RIPK3:sorafenib, ponatinib, pazopanib [cytosol]
releaseDate
2020-09-15
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:9692900] D'Eustachio, Peter, 2020-06-26
[InstanceEdit:9698846] Murphy, James M, 2020-08-28
schemaClass
Reaction
species
[Species:48887] Homo sapiens
stId
R-HSA-9693978
summation
[Summation:9693990] Several FDA-approved anticancer drugs, including sorafenib, ...
Referrals
(hasEvent)
[Pathway:R-HSA-5675482] Regulation of necroptotic cell death
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