Reactome | HTR1A binds HTR1A agonists

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HTR1A binds HTR1A agonists Show undefined attributes

authored	[InstanceEdit:9724665] Jassal, Bijay, 2021-03-25
category	binding
compartment	[Compartment:876] plasma membrane [Compartment:984] extracellular region
created	[InstanceEdit:9693487] Jassal, Bijay, 2020-07-01
dbId	9693478
definition	Agonist
displayName	HTR1A binds HTR1A agonists
edited	[InstanceEdit:9757169] Jassal, Bijay, 2021-10-27 [InstanceEdit:9773839] Matthews, Lisa, 2022-05-10
eventOf	[Pathway:R-HSA-390666] Serotonin receptors - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-390971] HTR1A [plasma membrane] [DefinedSet:R-ALL-9693410] HTR1A agonists [extracellular region]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9653916] Differential actions of antiparkinson agents at multiple classes of monoaminergic receptor. I. A multivariate analysis of the binding profiles of 14 drugs at 21 native and cloned human receptor subtypes [LiteratureReference:9648205] Agonist activity of antimigraine drugs at recombinant human 5-HT1A receptors: potential implications for prophylactic and acute therapy [LiteratureReference:9648208] Labelling of recombinant human and native rat serotonin 5-HT1A receptors by a novel, selective radioligand, [3H]-S 15535: definition of its binding profile using agonists, antagonists and inverse agonists [LiteratureReference:9693437] Pharmacology of flibanserin [LiteratureReference:9693460] N-Methyl-5-tert-butyltryptamine: A novel, highly potent 5-HT1D receptor agonist [LiteratureReference:9693459] Discovery of 1-[2-(2,4-dimethylphenylsulfanyl)phenyl]piperazine (Lu AA21004): a novel multimodal compound for the treatment of major depressive disorder [LiteratureReference:9648174] S 16924 ((R)-2-[1-[2-(2,3-dihydro-benzo[1,4] dioxin-5-Yloxy)-ethyl]-pyrrolidin-3yl]-1-(4-fluoro-phenyl)-ethanone), a novel, potential antipsychotic with marked serotonin (5-HT)1A agonist properties: I. Receptorial and neurochemical profile in comparison with clozapine and haloperidol [LiteratureReference:9693407] Characterisation of the 5-HT receptor binding profile of eletriptan and kinetics of [3H]eletriptan binding at human 5-HT1B and 5-HT1D receptors [LiteratureReference:9693429] Vilazodone: a 5-HT1A receptor agonist/serotonin transporter inhibitor for the treatment of affective disorders [LiteratureReference:9693444] Synthesis and structure--activity relationship in a class of indolebutylpiperazines as dual 5-HT(1A) receptor agonists and serotonin reuptake inhibitors [LiteratureReference:9693482] Aripiprazole, a novel atypical antipsychotic drug with a unique and robust pharmacology [LiteratureReference:9648191] High-level stable expression of recombinant 5-HT1A 5-hydroxytryptamine receptors in Chinese hamster ovary cells [LiteratureReference:9648322] Risperidone compared with new and reference antipsychotic drugs: in vitro and in vivo receptor binding [LiteratureReference:9648204] Agonist and antagonist actions of antipsychotic agents at 5-HT1A receptors: a [35S]GTPgammaS binding study [LiteratureReference:9693513] Buspirone: an update on a unique anxiolytic agent
maxDepth	1
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	HTR1A binds HTR1A agonists
orthologousEvent	[Reaction:R-CEL-9693478] HTR1A binds HTR1A agonists - Caenorhabditis elegans [Reaction:R-DME-9693478] HTR1A binds HTR1A agonists - Drosophila melanogaster [Reaction:R-GGA-9693478] HTR1A binds HTR1A agonists - Gallus gallus [Reaction:R-DRE-9693478] HTR1A binds HTR1A agonists - Danio rerio [Reaction:R-BTA-9693478] HTR1A binds HTR1A agonists - Bos taurus [Reaction:R-CFA-9693478] HTR1A binds HTR1A agonists - Canis familiaris [Reaction:R-RNO-9693478] HTR1A binds HTR1A agonists - Rattus norvegicus [Reaction:R-MMU-9693478] HTR1A binds HTR1A agonists - Mus musculus
output	[Complex:R-HSA-9693427] HTR1A:HTR1A agonists [plasma membrane]
releaseDate	2022-06-09
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9767610] Huddart, Rachel, 2022-03-01
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9693478
summation	[Summation:9693511] The serotonin 1A receptor (HTR1A), encoded by the HTR1A gene...

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[Pathway:R-HSA-390666] Serotonin receptors

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