The serotonin 1A receptor (HTR1A), encoded by the HTR1A gene...

created [InstanceEdit:9693510] Jassal, Bijay, 2020-07-01
dbId 9693511
displayName The serotonin 1A receptor (HTR1A), encoded by the HTR1A gene...
modified [InstanceEdit:9693543] Jassal, Bijay, 2020-07-02
schemaClass Summation
text The serotonin 1A receptor (HTR1A), encoded by the HTR1A gene, binds the neurotransmitter serotonin (5-hydroxytryptamine, 5HT). It is a G protein-coupled receptor (GPCR), coupled to the Gi protein, that mediates inhibitory neurotransmission. HTR1A is the most widespread of all the HTR1 receptors, mainly throughout the central nervous system. Dysfunctions associated with abnormal HTR1A neurotransmission are linked to several psychiatric disorders, including anxiety, depression, and movement disorders.

HTR1A is seen to be a promising target for HTR1A agonist drugs to alleviate anxiety and depression in schizophrenia (Newman-Tancredi et al. 1998). The prototype HTR1A agonist drug buspirone was originally developed as an antipsychotic drug for the treatment of schizophrenia. It was found to be ineffective for the treatment of schizophrenia but clinically it showed significant anxiolytic actions (Jann 1988).
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