Reactome | FLT3 K663Q [plasma membrane]

Schema > EntityWithAccessionedSequence > Entries

compartment	[Compartment:876] plasma membrane
componentOf	[Complex:R-HSA-9691981] FLT3 K663Q dimer [plasma membrane] - Homo sapiens [Complex:R-HSA-9691981] FLT3 K663Q dimer [plasma membrane] - Homo sapiens
created	[InstanceEdit:9691897] Rothfels, Karen, 2020-06-19
crossReference	[DatabaseIdentifier:12020776] Mondo:0018874 [DatabaseIdentifier:9691862] COSMIC:COSV54065828
dbId	9691908
disease	[Disease:1500689] cancer [Disease:9630839] acute myeloid leukemia [Disease:2317476] acute lymphocytic leukemia
displayName	FLT3 K663Q [plasma membrane]
endCoordinate	993
hasModifiedResidue	[ReplacedResidue:9691887] L-lysine 663 replaced with L-glutamine
inDisease	true
literatureReference	[LiteratureReference:9691860] FLT3 K663Q is a novel AML-associated oncogenic kinase: Determination of biochemical properties and sensitivity to Sunitinib (SU11248)
maxDepth	1
memberOf	[DefinedSet:R-HSA-9699532] sunitinib-sensitive FLT3 mutants [plasma membrane] - Homo sapiens [CandidateSet:R-HSA-9682396] kinase domain mutants of FLT3 [plasma membrane] - Homo sapiens
modified	[InstanceEdit:9699473] Rothfels, Karen, 2020-09-14
name	FLT3 K663Q STK-1
referenceEntity	[ReferenceGeneProduct:uniprot:P36888] UniProt:P36888 FLT3
referenceType	ReferenceGeneProduct
schemaClass	EntityWithAccessionedSequence
species	[Species:48887] Homo sapiens
stId	R-HSA-9691908
startCoordinate	27

(hasMember)	[DefinedSet:R-HSA-9699532] sunitinib-sensitive FLT3 mutants [plasma membrane] [CandidateSet:R-HSA-9682396] kinase domain mutants of FLT3 [plasma membrane]
(hasComponent)	[Complex:R-HSA-9691981] FLT3 K663Q dimer [plasma membrane]

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