Reactome | p-6Y FLT3 V579A [plasma membrane]

Schema > EntityWithAccessionedSequence > Entries

compartment	[Compartment:876] plasma membrane
componentOf	[Complex:R-HSA-9691103] p-6Y FLT3 V579A dimer [plasma membrane] - Homo sapiens [Complex:R-HSA-9691103] p-6Y FLT3 V579A dimer [plasma membrane] - Homo sapiens
created	[InstanceEdit:9691063] Rothfels, Karen, 2020-06-08
crossReference	[DatabaseIdentifier:12020776] Mondo:0018874 [DatabaseIdentifier:9691032] COSMIC:COSV54077224
dbId	9691066
disease	[Disease:1500689] cancer [Disease:9630839] acute myeloid leukemia
displayName	p-6Y FLT3 V579A [plasma membrane]
endCoordinate	993
hasModifiedResidue	[ReplacedResidue:9691043] L-valine 579 replaced with L-alanine [ModifiedResidue:9604760] O4'-phospho-L-tyrosine at 589 [ModifiedResidue:9604750] O4'-phospho-L-tyrosine at 591 [ModifiedResidue:9604772] O4'-phospho-L-tyrosine at 599 [ModifiedResidue:9604762] O4'-phospho-L-tyrosine at 768 [ModifiedResidue:9604765] O4'-phospho-L-tyrosine at 955 [ModifiedResidue:9604743] O4'-phospho-L-tyrosine at 969
inDisease	true
literatureReference	[LiteratureReference:9691015] Point mutations in the juxtamembrane domain of FLT3 define a new class of activating mutations in AML [LiteratureReference:9691008] Novel FLT3 point mutations within exon 14 found in patients with acute myeloid leukaemia
maxDepth	1
name	p-6Y FLT3 V579A STK-1
referenceEntity	[ReferenceGeneProduct:uniprot:P36888] UniProt:P36888 FLT3
referenceType	ReferenceGeneProduct
schemaClass	EntityWithAccessionedSequence
species	[Species:48887] Homo sapiens
stId	R-HSA-9691066
startCoordinate	27

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