Reactome | FLT3 F590G Y591D [plasma membrane]

Schema > EntityWithAccessionedSequence > Entries

compartment	[Compartment:876] plasma membrane
componentOf	[Complex:R-HSA-9691112] FLT3 F590G Y591D dimer [plasma membrane] - Homo sapiens [Complex:R-HSA-9691112] FLT3 F590G Y591D dimer [plasma membrane] - Homo sapiens
created	[InstanceEdit:9691063] Rothfels, Karen, 2020-06-08
crossReference	[DatabaseIdentifier:12020776] Mondo:0018874
dbId	9691062
disease	[Disease:1500689] cancer [Disease:9630839] acute myeloid leukemia
displayName	FLT3 F590G Y591D [plasma membrane]
endCoordinate	993
hasModifiedResidue	[ReplacedResidue:9691040] L-phenylalanine 590 replaced with glycine [ReplacedResidue:9691037] L-tyrosine 591 replaced with L-aspartic acid
inDisease	true
literatureReference	[LiteratureReference:9691008] Novel FLT3 point mutations within exon 14 found in patients with acute myeloid leukaemia [LiteratureReference:9691015] Point mutations in the juxtamembrane domain of FLT3 define a new class of activating mutations in AML
maxDepth	1
memberOf	[CandidateSet:R-HSA-9691152] juxtamembrane domain mutants of FLT3 [plasma membrane] - Homo sapiens
name	FLT3 F590G Y591D STK-1
referenceEntity	[ReferenceGeneProduct:uniprot:P36888] UniProt:P36888 FLT3
referenceType	ReferenceGeneProduct
schemaClass	EntityWithAccessionedSequence
species	[Species:48887] Homo sapiens
stId	R-HSA-9691062
startCoordinate	27

(hasMember)	[CandidateSet:R-HSA-9691152] juxtamembrane domain mutants of FLT3 [plasma membrane]
(hasComponent)	[Complex:R-HSA-9691112] FLT3 F590G Y591D dimer [plasma membrane]

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