Reactome | S1PR1 bind S1P

Schema > Reaction > Entries

S1PR1 bind S1P Show undefined attributes

authored	[InstanceEdit:419301] Jassal, Bijay, 2009-04-30
category	binding
compartment	[Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:9690448] Jassal, Bijay, 2020-06-01
dbId	9690449
displayName	S1PR1 bind S1P
eventOf	[Pathway:R-HSA-419408] Lysosphingolipid and LPA receptors - Homo sapiens
input	[SimpleEntity:R-ALL-419305] C18-S1P [extracellular region] [EntityWithAccessionedSequence:R-HSA-419340] S1PR1 [plasma membrane]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:419337] An abundant transcript induced in differentiating human endothelial cells encodes a polypeptide with structural similarities to G-protein-coupled receptors [LiteratureReference:419319] The inducible G protein-coupled receptor edg-1 signals via the G(i)/mitogen-activated protein kinase pathway [LiteratureReference:419329] Sphingosine 1-phosphate-induced cell proliferation, survival, and related signaling events mediated by G protein-coupled receptors Edg3 and Edg5 [LiteratureReference:419380] Differential coupling of the sphingosine 1-phosphate receptors Edg-1, Edg-3, and H218/Edg-5 to the G(i), G(q), and G(12) families of heterotrimeric G proteins [LiteratureReference:419377] Molecular cloning of the novel human G protein-coupled receptor (GPCR) gene mapped on chromosome 9 [LiteratureReference:419350] Sphingosine-1-phosphate is a ligand for the G protein-coupled receptor EDG-6 [LiteratureReference:419315] Characterization of a human sphingosine-1-phosphate receptor gene (S1P5) and its differential expression in LGL leukemia [LiteratureReference:419361] Characterization of a novel sphingosine 1-phosphate receptor, Edg-8
maxDepth	1
modified	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name	S1PR1 bind S1P
orthologousEvent	[Reaction:R-GGA-9690449] S1PR1 bind S1P - Gallus gallus [Reaction:R-XTR-9690449] S1PR1 bind S1P - Xenopus tropicalis [Reaction:R-DRE-9690449] S1PR1 bind S1P - Danio rerio [Reaction:R-SSC-9690449] S1PR1 bind S1P - Sus scrofa [Reaction:R-BTA-9690449] S1PR1 bind S1P - Bos taurus [Reaction:R-CFA-9690449] S1PR1 bind S1P - Canis familiaris [Reaction:R-RNO-9690449] S1PR1 bind S1P - Rattus norvegicus [Reaction:R-MMU-9690449] S1PR1 bind S1P - Mus musculus
output	[Complex:R-HSA-9690450] S1PR1:S1P [plasma membrane]
precedingEvent	[Reaction:R-HSA-9695890] SPNS2,MFSD2B transport S1P from cytosol to extracellular region - Homo sapiens [Reaction:R-HSA-9678854] S1PR1 binds S1PR1 agonists - Homo sapiens
regulatedBy	[PositiveRegulation:9690451] Positive regulation by 'S1PR1:S1PR1 agonists [plasma membrane]'
releaseDate	2009-06-24
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:422381] D'Eustachio, P, 2009-05-29 07:44:22
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9690449
summation	[Summation:9690452] The human gene EDG1 encodes S1PR1 which binds sphingosine 1-...

Referrals

(hasEvent)

[Pathway:R-HSA-419408] Lysosphingolipid and LPA receptors

Cite Us!