Reactome | S1PR1 bind S1P

S1PR1 bind S1P

Stable Identifier

R-HSA-9690449

Type

Reaction [binding]

Species

Homo sapiens

Compartment

extracellular region, plasma membrane

ReviewStatus

5/5

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The human gene EDG1 encodes S1PR1 which binds sphingosine 1-phosphate (S1P), a second messenger implicated in cell survival, cell migration, and inflammation (Hla & Maciag 1990). S1PR1 seems to couple with Gi proteins (Lee et al. 1996).

Literature References

PubMed ID	Title	Journal	Year
2160972	An abundant transcript induced in differentiating human endothelial cells encodes a polypeptide with structural similarities to G-protein-coupled receptors Hla, T, Maciag, T	J Biol Chem	1990
10799507	Characterization of a novel sphingosine 1-phosphate receptor, Edg-8 McAllister, G, George, SR, Heavens, RP, Mandala, S, Hla, T, Rigby, MR, O'Dowd, BF, Ancellin, N, Shei, GJ, Lynch, KR, Im, DS, Heise, CE	J Biol Chem	2000
8878560	Molecular cloning of the novel human G protein-coupled receptor (GPCR) gene mapped on chromosome 9 Tokuda, M, Hatase, O, Yamaguchi, F, Brenner, S	Biochem Biophys Res Commun	1996
10617617	Sphingosine 1-phosphate-induced cell proliferation, survival, and related signaling events mediated by G protein-coupled receptors Edg3 and Edg5 An, S, Zheng, Y, Bleu, T	J Biol Chem	2000
12427546	Characterization of a human sphingosine-1-phosphate receptor gene (S1P5) and its differential expression in LGL leukemia Kothapalli, R, Kusmartseva, I, Loughran, TP	Biochim Biophys Acta	2002
10488065	Differential coupling of the sphingosine 1-phosphate receptors Edg-1, Edg-3, and H218/Edg-5 to the G(i), G(q), and G(12) families of heterotrimeric G proteins Windh, RT, Hla, T, An, S, Barr, AJ, Manning, DR, Lee, MJ	J Biol Chem	1999
8626678	The inducible G protein-coupled receptor edg-1 signals via the G(i)/mitogen-activated protein kinase pathway Hla, T, Evans, M, Lee, MJ	J Biol Chem	1996
10753843	Sphingosine-1-phosphate is a ligand for the G protein-coupled receptor EDG-6 Gräler, MH, Lipp, M, Spiegel, S, Hobson, JP, Van Brocklyn, JR, Bernhardt, G	Blood	2000