Reactome | Nsp3, nsp4, and nsp6 produce replicative organelles

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Nsp3, nsp4, and nsp6 produce replicative organelles Show undefined attributes

authored	[InstanceEdit:9684895] Stephan, Ralf, 2020-04-22
category	omitted
compartment	[Compartment:12045] endoplasmic reticulum membrane [Compartment:9684675] double membrane vesicle viral factory outer membrane
created	[InstanceEdit:9686025] Stephan, Ralf, 2020-04-28
crossReference	[DatabaseIdentifier:12020764] Mondo:0005091
dbId	9686015
disease	[Disease:9678120] severe acute respiratory syndrome
displayName	Nsp3, nsp4, and nsp6 produce replicative organelles
edited	[InstanceEdit:9689806] D'Eustachio, Peter, 2020-05-21
eventOf	[Pathway:R-HSA-9679504] Translation of Replicase and Assembly of the Replication Transcription Complex - Homo sapiens
followingEvent	[BlackBoxEvent:R-HSA-9686013] Nsp3:nsp4 binds to nsp6 - Homo sapiens
input	[DefinedSet:R-COV-9682205] N-glycan nsp3 [endoplasmic reticulum membrane] [DefinedSet:R-COV-9684875] N-glycan nsp4 [endoplasmic reticulum membrane] [DefinedSet:R-COV-9682227] nsp6 [endoplasmic reticulum membrane]
isChimeric	false
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:9686027] Coronavirus NSP6 restricts autophagosome expansion [LiteratureReference:9686000] Coronaviruses Hijack the LC3-I-positive EDEMosomes, ER-derived vesicles exporting short-lived ERAD regulators, for replication [LiteratureReference:9686031] Severe acute respiratory syndrome coronavirus nonstructural proteins 3, 4, and 6 induce double-membrane vesicles [LiteratureReference:9686010] Two-amino acids change in the nsp4 of SARS coronavirus abolishes viral replication
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Nsp3, nsp4, and nsp6 produce replicative organelles
orthologousEvent	[BlackBoxEvent:R-HSA-9694317] Nsp3, nsp4, and nsp6 produce replicative organelles - Homo sapiens
output	[Complex:R-COV-9686003] nsp3:nsp4 [double membrane vesicle viral factory outer membrane] [DefinedSet:R-COV-9686011] nsp6 [double membrane vesicle viral factory outer membrane]
precedingEvent	[BlackBoxEvent:R-HSA-9684290] nsp3 is glycosylated - Homo sapiens [BlackBoxEvent:R-HSA-9684261] nsp4 is glycosylated - Homo sapiens
relatedSpecies	[Species:9678119] Human SARS coronavirus
releaseDate	2020-06-10
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9690206] Acencio, Marcio Luis, Mazein, Alexander, 2020-05-27
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-9686015
summation	[Summation:9686026] nsp3 and nsp4 alone caused considerable ER membrane deformat...

Referrals

(hasEvent)	[Pathway:R-HSA-9679504] Translation of Replicase and Assembly of the Replication Transcription Complex
(precedingEvent)	[BlackBoxEvent:R-HSA-9686013] Nsp3:nsp4 binds to nsp6

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