Reactome | 3a localizes to the cell membrane

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3a localizes to the cell membrane Show undefined attributes

authored	[InstanceEdit:9685954] Stephan, Ralf, 2020-04-28
category	uncertain
compartment	[Compartment:190626] endoplasmic reticulum-Golgi intermediate compartment [Compartment:876] plasma membrane
created	[InstanceEdit:9685954] Stephan, Ralf, 2020-04-28
crossReference	[DatabaseIdentifier:12020764] Mondo:0005091
dbId	9685939
disease	[Disease:9678120] severe acute respiratory syndrome
displayName	3a localizes to the cell membrane
edited	[InstanceEdit:9689806] D'Eustachio, Peter, 2020-05-21
eventOf	[Pathway:R-HSA-9683673] Maturation of protein 3a - Homo sapiens
followingEvent	[Reaction:R-HSA-9731057] SARS-CoV-1 3a binds to caspase-1 - Homo sapiens [BlackBoxEvent:R-HSA-9685950] Endocytosis of protein 3a - Homo sapiens [BlackBoxEvent:R-HSA-9685956] 3a is externalized together with membrane structures - Homo sapiens [Reaction:R-HSA-9731072] SARS-CoV-1 3a tetramer induces potassium efflux - Homo sapiens
input	[Complex:R-COV-9685967] O-glycosyl 3a tetramer [endoplasmic reticulum-Golgi intermediate compartment membrane]
isChimeric	false
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:9682779] A novel severe acute respiratory syndrome coronavirus protein, U274, is transported to the cell surface and undergoes endocytosis [LiteratureReference:9685946] The ion channel activity of the SARS-coronavirus 3a protein is linked to its pro-apoptotic function
maxDepth	1
modified	[InstanceEdit:9937649] Stephan, Ralf, 2025-02-05
name	3a localizes to the cell membrane
output	[EntityWithAccessionedSequence:R-COV-9685962] O-glycosyl 3a [plasma membrane]
precedingEvent	[BlackBoxEvent:R-HSA-9685956] 3a is externalized together with membrane structures - Homo sapiens [Reaction:R-HSA-9683769] O-glycosylation of 3a is terminated - Homo sapiens
relatedSpecies	[Species:9678119] Human SARS coronavirus
releaseDate	2020-06-10
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9690206] Acencio, Marcio Luis, Mazein, Alexander, 2020-05-27
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-9685939
summation	[Summation:9685945] As it contains cargo sorting motifs in its cytoplasmic domai...

Referrals

(precedingEvent)	[Reaction:R-HSA-9731057] SARS-CoV-1 3a binds to caspase-1 [Reaction:R-HSA-9731072] SARS-CoV-1 3a tetramer induces potassium efflux [BlackBoxEvent:R-HSA-9685950] Endocytosis of protein 3a [BlackBoxEvent:R-HSA-9685956] 3a is externalized together with membrane structures
(hasEvent)	[Pathway:R-HSA-9683673] Maturation of protein 3a