3a localizes to the cell membrane

Stable Identifier
Reaction [uncertain]
Homo sapiens
Related Species
Human SARS coronavirus
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As it contains cargo sorting motifs in its cytoplasmic domain, protein 3a gets localized by the cell's protein transport system to the cell membrane where it functions as an ion channel (Tan et al, 2004). This ion channel function is necessary for the protein's pro-apoptotic function (Chan et al, 2009).

Literature References
PubMed ID Title Journal Year
15194747 A novel severe acute respiratory syndrome coronavirus protein, U274, is transported to the cell surface and undergoes endocytosis

Tan, YJ, Teng, E, Shen, S, Tan, TH, Goh, PY, Fielding, BC, Ooi, EE, Tan, HC, Lim, SG, Hong, W

J. Virol. 2004
19398035 The ion channel activity of the SARS-coronavirus 3a protein is linked to its pro-apoptotic function

Chan, CM, Tsoi, H, Chan, WM, Zhai, S, Wong, CO, Yao, X, Chan, WY, Tsui, SK, Chan, HY

Int. J. Biochem. Cell Biol. 2009
Orthologous Events
Name Identifier Synonyms
severe acute respiratory syndrome DOID:2945 SARS-CoV infection, SARS
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