Reactome | Protein 3a forms a homotetramer

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Protein 3a forms a homotetramer Show undefined attributes

authored	[InstanceEdit:9683645] Stephan, Ralf, 2020-04-08
category	binding
compartment	[Compartment:6791047] endoplasmic reticulum-Golgi intermediate compartment membrane
created	[InstanceEdit:9683729] Stephan, Ralf, 2020-04-17
crossReference	[DatabaseIdentifier:12020764] Mondo:0005091
dbId	9683746
disease	[Disease:9678120] severe acute respiratory syndrome
displayName	Protein 3a forms a homotetramer
edited	[InstanceEdit:9689806] D'Eustachio, Peter, 2020-05-21
eventOf	[Pathway:R-HSA-9683673] Maturation of protein 3a - Homo sapiens
followingEvent	[Reaction:R-HSA-9731034] SARS-CoV-1 3a tetramer binds to CAV1 - Homo sapiens [Reaction:R-HSA-9686174] Accessory proteins are recruited to the maturing virion - Homo sapiens
input	4 × [EntityWithAccessionedSequence:R-COV-9683640] O-glycosyl 3a [endoplasmic reticulum-Golgi intermediate compartment membrane]
isChimeric	false
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:9683023] Severe Acute Respiratory Syndrome Coronavirus Viroporin 3a Activates the NLRP3 Inflammasome
maxDepth	1
modified	[InstanceEdit:9937650] Stephan, Ralf, 2025-02-05
name	Protein 3a forms a homotetramer
output	[Complex:R-COV-9685967] O-glycosyl 3a tetramer [endoplasmic reticulum-Golgi intermediate compartment membrane]
precedingEvent	[Reaction:R-HSA-9683769] O-glycosylation of 3a is terminated - Homo sapiens
relatedSpecies	[Species:9678119] Human SARS coronavirus
releaseDate	2020-06-10
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9690206] Acencio, Marcio Luis, Mazein, Alexander, 2020-05-27
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9683746
summation	[Summation:9683013] Protein 3a can form homodimers and tetramers. The homotetram...

Referrals

(hasEvent)	[Pathway:R-HSA-9683673] Maturation of protein 3a
(precedingEvent)	[Reaction:R-HSA-9731034] SARS-CoV-1 3a tetramer binds to CAV1 [Reaction:R-HSA-9686174] Accessory proteins are recruited to the maturing virion

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