Reactome | p-6Y FLT3 D835E [plasma membrane]

Schema > EntityWithAccessionedSequence > Entries

compartment	[Compartment:876] plasma membrane
componentOf	[Complex:R-HSA-9682386] p-6Y FLT3 D835E dimer [plasma membrane] - Homo sapiens
created	[InstanceEdit:9682381] Rothfels, Karen, 2020-04-08
crossReference	[DatabaseIdentifier:9682295] COSMIC:COSV54045054 [DatabaseIdentifier:9682293] COSMIC:COSV54044297 [DatabaseIdentifier:9682298] COSMIC:COSM19436
dbId	9682395
disease	[Disease:1500689] cancer [Disease:9630839] acute myeloid leukemia
displayName	p-6Y FLT3 D835E [plasma membrane]
endCoordinate	993
hasModifiedResidue	[ReplacedResidue:9682294] L-aspartic acid 835 replaced with L-glutamic acid [ModifiedResidue:9604760] O4'-phospho-L-tyrosine at 589 [ModifiedResidue:9604750] O4'-phospho-L-tyrosine at 591 [ModifiedResidue:9604772] O4'-phospho-L-tyrosine at 599 [ModifiedResidue:9604762] O4'-phospho-L-tyrosine at 768 [ModifiedResidue:9604765] O4'-phospho-L-tyrosine at 955 [ModifiedResidue:9604743] O4'-phospho-L-tyrosine at 969
inDisease	true
literatureReference	[LiteratureReference:9682272] Activating mutation of D835 within the activation loop of FLT3 in human hematologic malignancies
name	p-6Y FLT3 D835E STK-1
referenceEntity	[ReferenceGeneProduct:54914] UniProt:P36888 FLT3
referenceType	ReferenceGeneProduct
schemaClass	EntityWithAccessionedSequence
species	[Species:48887] Homo sapiens
stId	R-HSA-9682395
startCoordinate	27

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