Reactome | PIK3CA,B,D:PIK3R1 [cytosol]

Schema > DefinedSet > Entries

compartment	[Compartment:70101] cytosol
consumedByEvent	[BlackBoxEvent:R-HSA-9680348] PIK3R1:PIK3CA,B,D (PI3K), PLCG2 (PLCgamma2), SHC1 (SHC), PTPN11 (SHP2), GRB2:GAB2, GRB2:GAB3, GRAP2 (MONA), CBL:GRB2, INPP5D (SHIP1), INPPL1 (SHIP2) bind PolyUb,p-8Y-CSF1R and are activated - Homo sapiens
created	[InstanceEdit:9680354] May, Bruce, 2020-03-27
dbId	9680346
displayName	PIK3CA,B,D:PIK3R1 [cytosol]
hasMember	[Complex:R-HSA-1806218] PIK3CA:PIK3R1 [cytosol] - Homo sapiens [Complex:R-HSA-1806184] PIK3CB:PIK3R1 [cytosol] - Homo sapiens [Complex:R-HSA-1806213] PIK3CD:PIK3R1 [cytosol] - Homo sapiens
inDisease	false
maxDepth	3
modified	[InstanceEdit:9860456] May, Bruce, 2024-02-07
name	PIK3CA,B,D:PIK3R1
schemaClass	DefinedSet
species	[Species:48887] Homo sapiens
stId	R-HSA-9680346

(activeUnit)	[CatalystActivity:9680386] 1-phosphatidylinositol-3-kinase activity of CSF1 dimer,IL34 dimer:PolyUb,p-8Y-CSF1R dimer:p-Y-CBL:GRB2:SOS1:p-Y-GAB2:p-Y-GAB3:GRAP2:INPP5D:INPPL1:PI3K:PTPN11:p-Y-SHC1:p-Y-PLCG2 [plasma membrane]
(input)	[BlackBoxEvent:R-HSA-9680348] PIK3R1:PIK3CA,B,D (PI3K), PLCG2 (PLCgamma2), SHC1 (SHC), PTPN11 (SHP2), GRB2:GAB2, GRB2:GAB3, GRAP2 (MONA), CBL:GRB2, INPP5D (SHIP1), INPPL1 (SHIP2) bind PolyUb,p-8Y-CSF1R and are activated