Reactome | p7Y-KIT D419A [plasma membrane]

Schema > EntityWithAccessionedSequence > Entries

compartment	[Compartment:876] plasma membrane
componentOf	[Complex:R-HSA-9680128] p7Y-KIT D419A dimer [plasma membrane] - Homo sapiens [Complex:R-HSA-9680128] p7Y-KIT D419A dimer [plasma membrane] - Homo sapiens
created	[InstanceEdit:9680126] Rothfels, Karen, 2020-03-25
crossReference	[DatabaseIdentifier:12020776] Mondo:0018874 [DatabaseIdentifier:9680019] COSMIC:COSV55416458
dbId	9680129
disease	[Disease:9630839] acute myeloid leukemia [Disease:1500689] cancer
displayName	p7Y-KIT D419A [plasma membrane]
endCoordinate	976
hasModifiedResidue	[ReplacedResidue:9680052] L-aspartic acid 419 replaced with L-alanine [ModifiedResidue:205176] O4'-phospho-L-tyrosine at 568 [ModifiedResidue:205169] O4'-phospho-L-tyrosine at 570 [ModifiedResidue:205278] O4'-phospho-L-tyrosine at 703 [ModifiedResidue:205171] O4'-phospho-L-tyrosine at 721 [ModifiedResidue:205288] O4'-phospho-L-tyrosine at 730 [ModifiedResidue:205235] O4'-phospho-L-tyrosine at 823 [ModifiedResidue:205246] O4'-phospho-L-tyrosine at 936
inDisease	true
literatureReference	[LiteratureReference:9679992] Extracellular KIT receptor mutants, commonly found in core binding factor AML, are constitutively active and respond to imatinib mesylate
maxDepth	1
name	p7Y-KIT D419A
referenceEntity	[ReferenceGeneProduct:uniprot:P10721] UniProt:P10721 KIT
referenceType	ReferenceGeneProduct
schemaClass	EntityWithAccessionedSequence
species	[Species:48887] Homo sapiens
stId	R-HSA-9680129
startCoordinate	26

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