Reactome | VEGFA-165 dimer binds VEGFA inhibitors

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VEGFA-165 dimer binds VEGFA inhibitors Show undefined attributes

authored	[InstanceEdit:9679468] Jassal, Bijay, 2020-03-24
category	binding
compartment	[Compartment:984] extracellular region
created	[InstanceEdit:9679468] Jassal, Bijay, 2020-03-24
dbId	9679477
displayName	VEGFA-165 dimer binds VEGFA inhibitors
edited	[InstanceEdit:9679468] Jassal, Bijay, 2020-03-24
eventOf	[Pathway:R-HSA-4420097] VEGFA-VEGFR2 Pathway - Homo sapiens [Pathway:R-HSA-9679191] Potential therapeutics for SARS - Homo sapiens
input	[CandidateSet:R-ALL-9679456] VEGFA inhibitors [extracellular region] [Complex:R-HSA-4420158] VEGFA-165 dimer [extracellular region]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9679491] Aflibercept (AVE0005): an alternative strategy for inhibiting tumour angiogenesis by vascular endothelial growth factors [LiteratureReference:9679484] Aflibercept in the treatment of patients with metastatic colorectal cancer: latest findings and interpretations [LiteratureReference:9679489] Treatment of diabetic macular edema with a designed ankyrin repeat protein that binds vascular endothelial growth factor: a phase I/II study [LiteratureReference:9685108] VEGF-A and ICAM-1 Gene Polymorphisms as Predictors of Clinical Outcome to First-Line Bevacizumab-Based Treatment in Metastatic Colorectal Cancer [LiteratureReference:9685080] Brolucizumab: evidence to date in the treatment of neovascular age-related macular degeneration [LiteratureReference:9679454] Pegaptanib for neovascular age-related macular degeneration [LiteratureReference:9685063] Pegaptanib in the treatment of wet, age-related macular degeneration [LiteratureReference:9685089] Development of ranibizumab, an anti-vascular endothelial growth factor antigen binding fragment, as therapy for neovascular age-related macular degeneration [LiteratureReference:9685068] Vascular endothelial growth factor is a critical stimulus for diabetic macular edema [LiteratureReference:9685083] First-in-Human Phase I Study of Single-agent Vanucizumab, A First-in-Class Bispecific Anti-Angiopoietin-2/Anti-VEGF-A Antibody, in Adult Patients with Advanced Solid Tumors [LiteratureReference:9685091] The McCAVE Trial: Vanucizumab plus mFOLFOX-6 Versus Bevacizumab plus mFOLFOX-6 in Patients with Previously Untreated Metastatic Colorectal Carcinoma (mCRC)
maxDepth	1
modified	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name	VEGFA-165 dimer binds VEGFA inhibitors
orthologousEvent	[Reaction:R-GGA-9679477] VEGFA-165 dimer binds VEGFA inhibitors - Gallus gallus [Reaction:R-XTR-9679477] VEGFA-165 dimer binds VEGFA inhibitors - Xenopus tropicalis [Reaction:R-DRE-9679477] VEGFA-165 dimer binds VEGFA inhibitors - Danio rerio [Reaction:R-SSC-9679477] VEGFA-165 dimer binds VEGFA inhibitors - Sus scrofa [Reaction:R-BTA-9679477] VEGFA-165 dimer binds VEGFA inhibitors - Bos taurus [Reaction:R-CFA-9679477] VEGFA-165 dimer binds VEGFA inhibitors - Canis familiaris [Reaction:R-RNO-9679477] VEGFA-165 dimer binds VEGFA inhibitors - Rattus norvegicus [Reaction:R-MMU-9679477] VEGFA-165 dimer binds VEGFA inhibitors - Mus musculus
output	[Complex:R-HSA-9679453] VEGFA-165 dimer:VEGFA inhibitors [extracellular region]
releaseDate	2020-06-10
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9688552] Shoichet, Brian, 2020-05-14
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9679477
summation	[Summation:9685053] In normal development vascular endothelial growth factors (V...
updateTrackers	[UpdateTracker:9776918] Update Tracker - [Reaction:9679477] VEGFA-165 dimer binds VEGFA inhibitors - v74:[add_removeInput]

Referrals

(updatedInstance)	[UpdateTracker:9776918] Update Tracker - [Reaction:9679477] VEGFA-165 dimer binds VEGFA inhibitors - v74:[add_removeInput]
(hasEvent)	[Pathway:R-HSA-9679191] Potential therapeutics for SARS [Pathway:R-HSA-4420097] VEGFA-VEGFR2 Pathway

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