Reactome | PDCD1 binds PDCD1 inhibitors

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PDCD1 binds PDCD1 inhibitors Show undefined attributes

authored	[InstanceEdit:9679442] Jassal, Bijay, 2020-03-24
category	binding
compartment	[Compartment:876] plasma membrane [Compartment:984] extracellular region
created	[InstanceEdit:9679442] Jassal, Bijay, 2020-03-24
dbId	9679421
definition	Inhibition
displayName	PDCD1 binds PDCD1 inhibitors
edited	[InstanceEdit:9679442] Jassal, Bijay, 2020-03-24
eventOf	[Pathway:R-HSA-389948] Co-inhibition by PD-1 - Homo sapiens [Pathway:R-HSA-9679191] Potential therapeutics for SARS - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-197604] PDCD1 [plasma membrane] [DefinedSet:R-ALL-9679406] PDCD1 inhibitors [extracellular region]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9685340] Camrelizumab: First Global Approval [LiteratureReference:9679440] Characterization of the Anti-PD-1 Antibody REGN2810 and Its Antitumor Activity in Human PD-1 Knock-In Mice [LiteratureReference:9685344] PD-1 Blockade with Cemiplimab in Advanced Cutaneous Squamous-Cell Carcinoma [LiteratureReference:9679417] Beyond the standard of care: a review of novel immunotherapy trials for the treatment of lung cancer [LiteratureReference:9679427] Clinical development of mAbs to block the PD1 pathway as an immunotherapy for cancer [LiteratureReference:9685346] PD-1/ PD-L1 blockade as a novel treatment for colorectal cancer [LiteratureReference:9685306] An unexpected N-terminal loop in PD-1 dominates binding by nivolumab
maxDepth	1
modified	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name	PDCD1 binds PDCD1 inhibitors
orthologousEvent	[Reaction:R-MMU-9679421] PDCD1 binds PDCD1 inhibitors - Mus musculus [Reaction:R-GGA-9679421] PDCD1 binds PDCD1 inhibitors - Gallus gallus [Reaction:R-SSC-9679421] PDCD1 binds PDCD1 inhibitors - Sus scrofa [Reaction:R-BTA-9679421] PDCD1 binds PDCD1 inhibitors - Bos taurus [Reaction:R-CFA-9679421] PDCD1 binds PDCD1 inhibitors - Canis familiaris [Reaction:R-RNO-9679421] PDCD1 binds PDCD1 inhibitors - Rattus norvegicus
output	[Complex:R-HSA-9679420] PDCD1:PDCD1 inhibitors [plasma membrane]
releaseDate	2020-06-10
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9688552] Shoichet, Brian, 2020-05-14
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9679421
summation	[Summation:9685298] Programmed cell death protein 1 (PDCD1, PD-1) is an immune c...

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