Reactome | C-ter TLR9 dimer binds HCQ

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C-ter TLR9 dimer binds HCQ Show undefined attributes

authored	[InstanceEdit:9678968] Jassal, Bijay, 2020-03-23
category	binding
compartment	[Compartment:74700] endosome membrane [Compartment:70101] cytosol
created	[InstanceEdit:9678968] Jassal, Bijay, 2020-03-23
dbId	9679045
definition	Antagonist
displayName	C-ter TLR9 dimer binds HCQ
edited	[InstanceEdit:9678968] Jassal, Bijay, 2020-03-23
eventOf	[Pathway:R-HSA-168138] Toll Like Receptor 9 (TLR9) Cascade - Homo sapiens [Pathway:R-HSA-9679191] Potential therapeutics for SARS - Homo sapiens
input	[Complex:R-HSA-1679581] C-ter-TLR9 dimer [endosome membrane] [ChemicalDrug:R-ALL-9678628] HCQ [cytosol]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9678611] Novel small molecule inhibitors of TLR7 and TLR9: mechanism of action and efficacy in vivo [LiteratureReference:9684981] Hydroxychloroquine: a multifaceted treatment in lupus
maxDepth	1
modified	[InstanceEdit:10447035] Weiser, Joel, 2026-03-16
name	C-ter TLR9 dimer binds HCQ
orthologousEvent	[Reaction:R-MMU-9679045] C-ter TLR9 dimer binds HCQ - Mus musculus [Reaction:R-SSC-9679045] C-ter TLR9 dimer binds HCQ - Sus scrofa [Reaction:R-BTA-9679045] C-ter TLR9 dimer binds HCQ - Bos taurus [Reaction:R-CFA-9679045] C-ter TLR9 dimer binds HCQ - Canis familiaris [Reaction:R-RNO-9679045] C-ter TLR9 dimer binds HCQ - Rattus norvegicus
output	[Complex:R-HSA-9678655] C-ter TLR9 dimer:HCQ [endosome membrane]
releaseDate	2020-06-10
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9688552] Shoichet, Brian, 2020-05-14
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9679045
summation	[Summation:9684990] Toll-like receptor 9 (TLR9) is a key component of innate and...
updateTrackers	[UpdateTracker:9776781] Update Tracker - [Reaction:9679045] C-ter TLR9 dimer binds HCQ - v74:[add_removeInput] [UpdateTracker:9864113] Update Tracker - [Reaction:9679045] C-ter TLR9 dimer binds HCQ - v88:[modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9776781] Update Tracker - [Reaction:9679045] C-ter TLR9 dimer binds HCQ - v74:[add_removeInput] [UpdateTracker:9864113] Update Tracker - [Reaction:9679045] C-ter TLR9 dimer binds HCQ - v88:[modifyText]
(hasEvent)	[Pathway:R-HSA-9679191] Potential therapeutics for SARS [Pathway:R-HSA-168138] Toll Like Receptor 9 (TLR9) Cascade