Reactome | Spike glycoprotein of SARS coronavirus binds ACE2 on host cell

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Spike glycoprotein of SARS coronavirus binds ACE2 on host cell Show undefined attributes

authored	[InstanceEdit:9684898] Gillespie, Marc E, 2020-04-22
category	binding
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:9678130] Orlic-Milacic, Marija, 2020-03-13
crossReference	[DatabaseIdentifier:12020764] Mondo:0005091
dbId	9678128
disease	[Disease:9678120] severe acute respiratory syndrome
displayName	Spike glycoprotein of SARS coronavirus binds ACE2 on host cell
edited	[InstanceEdit:9689807] D'Eustachio, Peter, 2020-05-21 [InstanceEdit:9690126] Gillespie, Marc E, 2020-05-26
eventOf	[Pathway:R-HSA-9678110] Attachment and Entry - Homo sapiens
followingEvent	[Reaction:R-HSA-9697423] Endocytosis of SARS-CoV-2 Virion - Homo sapiens [Reaction:R-HSA-9686731] TMPRSS2 Mediated SARS-CoV-1 Spike Protein Cleavage and Endocytosis - Homo sapiens [Reaction:R-HSA-9686711] Endocytosis of SARS-CoV-1 Virion - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-9683480] glycosylated-ACE2 [plasma membrane] [Complex:R-COV-9685506] S3:M:E:encapsidated SARS coronavirus genomic RNA: 7a:O-glycosyl 3a tetramer [extracellular region]
isChimeric	false
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:9678303] Angiotensin-converting enzyme 2 is a functional receptor for the SARS coronavirus [LiteratureReference:9678298] Structure of SARS coronavirus spike receptor-binding domain complexed with receptor [LiteratureReference:9683520] Angiotensin-converting enzyme 2 (ACE2) as a SARS-CoV-2 receptor: molecular mechanisms and potential therapeutic target [LiteratureReference:9687552] Mechanisms of coronavirus cell entry mediated by the viral spike protein
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Spike glycoprotein of SARS coronavirus binds ACE2 on host cell
output	[Complex:R-HSA-9686311] S3:M:E:encapsidated SARS coronavirus genomic RNA: 7a:O-glycosyl 3a tetramer:glycosylated-ACE2 [extracellular region]
precedingEvent	[BlackBoxEvent:R-HSA-9683488] ACE2 is glycosylated to glycosylated-ACE2 - Homo sapiens [Reaction:R-HSA-9685542] Viral release - Homo sapiens
relatedSpecies	[Species:9678119] Human SARS coronavirus
releaseDate	2020-06-10
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9690206] Acencio, Marcio Luis, Mazein, Alexander, 2020-05-27
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9678128
summation	[Summation:9687547] SARS-CoV-1 spike (S3a) protein, as a component of the S3:M:E...

Referrals

(hasEvent)	[Pathway:R-HSA-9678110] Attachment and Entry
(precedingEvent)	[Reaction:R-HSA-9697423] Endocytosis of SARS-CoV-2 Virion [Reaction:R-HSA-9686731] TMPRSS2 Mediated SARS-CoV-1 Spike Protein Cleavage and Endocytosis [Reaction:R-HSA-9686711] Endocytosis of SARS-CoV-1 Virion

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