Spike glycoprotein of SARS coronavirus binds ACE2 on host cell

Stable Identifier
R-HSA-9678128
Type
Reaction [binding]
Species
Homo sapiens
Related Species
Human SARS coronavirus
Compartment
plasma membrane
ReviewStatus
5/5
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Spike glycoprotein of SARS coronavirus binds ACE2 on host cell
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SARS-CoV-1 spike (S3a) protein, as a component of the S3:M:E:encapsidated SARS coronavirus genomic RNA: 7a:O-glycosyl 3a tetramer complex, binds to glycosylated angiotensin converting enzyme 2 (ACE2) associated with the human host cell plasma membrane. Structural studies of the interaction between human ACE2 protein and the receptor-binding domain of S3a protein have identified key amino acid residues in both proteins responsible for their high-affinity interaction. These residues may be a key factor determining severity (and possibly human-to-human transmission) of SARS-CoV-1 (Li et al. 2003, 2005). The roles of S protein in viral binding to the host cell membrane and fusion of viral and host cell membranes and thus the central role of S protein in determining the host range and tissue tropisms of the virus are reviewed by Belouzard et al. (2012).
Literature References
PubMed ID Title Journal Year
14647384 Angiotensin-converting enzyme 2 is a functional receptor for the SARS coronavirus

Sui, J, Vasilieva, N, Farzan, M, Berne, MA, Luzuriaga, K, Somasundaran, M, Moore, MJ, Sullivan, JL, Greenough, TC, Choe, H, Li, W, Wong, SK

Nature 2003
16166518 Structure of SARS coronavirus spike receptor-binding domain complexed with receptor

Li, F, Farzan, M, Harrison, SC, Li, W

Science 2005
22816037 Mechanisms of coronavirus cell entry mediated by the viral spike protein

Licitra, BN, Belouzard, S, Millet, JK, Whittaker, GR

Viruses 2012
32125455 Angiotensin-converting enzyme 2 (ACE2) as a SARS-CoV-2 receptor: molecular mechanisms and potential therapeutic target

Li, Y, Penninger, JM, Zhang, H, Slutsky, AS, Zhong, N

Intensive Care Med 2020
Participants
Input
Output
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as an event of
Disease
Name Identifier Synonyms
severe acute respiratory syndrome DOID:2945 SARS-CoV infection, SARS
Authored
Gillespie, ME  (2020-04-22)
Reviewed
Acencio, ML  (2020-05-27)
Mazein, A  (2020-05-27)
Created
Orlic-Milacic, M  (2020-03-13)
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